2yy2

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(New page: 200px<br /> <applet load="2yy2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2yy2, resolution 2.80&Aring;" /> '''Crystal structure o...)
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[[Image:2yy2.gif|left|200px]]<br />
 
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<applet load="2yy2" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2yy2, resolution 2.80&Aring;" />
 
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'''Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX'''<br />
 
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==About this Structure==
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==Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX==
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2YY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, MG and IBM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2YY2 OCA].
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<StructureSection load='2yy2' size='340' side='right'caption='[[2yy2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[2yy2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YY2 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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[[Category: Handa, N.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yy2 OCA], [https://pdbe.org/2yy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yy2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yy2 ProSAT]</span></td></tr>
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[[Category: Kotera, J.]]
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</table>
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[[Category: Omori, K.]]
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== Function ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
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[[Category: Shirouzu, M.]]
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== Evolutionary Conservation ==
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[[Category: Terada, T.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Yokoyama, S.]]
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Check<jmol>
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[[Category: IBM]]
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<jmolCheckbox>
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[[Category: MG]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yy/2yy2_consurf.spt"</scriptWhenChecked>
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[[Category: ZN]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: catalytic domain]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: hydrolase]]
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</jmolCheckbox>
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[[Category: national project on protein structural and functional analyses]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yy2 ConSurf].
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[[Category: nppsfa]]
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<div style="clear:both"></div>
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[[Category: phosphodiesterase]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:46:30 2007''
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Handa N]]
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[[Category: Kotera J]]
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[[Category: Omori K]]
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[[Category: Shirouzu M]]
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[[Category: Terada T]]
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[[Category: Yokoyama S]]

Current revision

Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX

PDB ID 2yy2

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