2z5d

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(New page: 200px<br /> <applet load="2z5d" size="450" color="white" frame="true" align="right" spinBox="true" caption="2z5d, resolution 2.10&Aring;" /> '''Human ubiquitin-con...)
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[[Image:2z5d.gif|left|200px]]<br />
 
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<applet load="2z5d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2z5d, resolution 2.10&Aring;" />
 
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'''Human ubiquitin-conjugating enzyme E2 H'''<br />
 
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==About this Structure==
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==Human ubiquitin-conjugating enzyme E2 H==
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2Z5D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. This structure superseeds the now removed PDB entry 1YH6. Active as [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA].
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<StructureSection load='2z5d' size='340' side='right'caption='[[2z5d]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2z5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yh6 1yh6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5D FirstGlance]. <br>
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[[Category: Ubiquitin--protein ligase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Arrowsmith, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Battaile, K.P.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5d OCA], [https://pdbe.org/2z5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5d RCSB], [https://www.ebi.ac.uk/pdbsum/2z5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5d ProSAT]</span></td></tr>
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[[Category: Bochkarev, A.]]
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</table>
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[[Category: Cui, H.]]
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== Function ==
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[[Category: Dhe-Paganon, S.]]
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[https://www.uniprot.org/uniprot/UBE2H_HUMAN UBE2H_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.<ref>PMID:8132613</ref> <ref>PMID:20061386</ref>
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[[Category: Edwards, A.]]
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== Evolutionary Conservation ==
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[[Category: Mackenzie, F.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Newman, E.M.]]
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Check<jmol>
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[[Category: SGC, Structural.Genomics.Consortium.]]
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<jmolCheckbox>
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[[Category: Sundstrom, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5d_consurf.spt"</scriptWhenChecked>
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[[Category: Walker, J.R.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: NA]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: ligase]]
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</jmolCheckbox>
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[[Category: sgc]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5d ConSurf].
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[[Category: structural genomics]]
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<div style="clear:both"></div>
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[[Category: structural genomics consortium]]
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[[Category: ube2h]]
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[[Category: ubiquitin]]
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[[Category: ubiquitin-conjugating enzyme]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:46:53 2007''
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==See Also==
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Battaile KP]]
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[[Category: Bochkarev A]]
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[[Category: Cui H]]
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[[Category: Dhe-Paganon S]]
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[[Category: Edwards A]]
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[[Category: Mackenzie F]]
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[[Category: Newman EM]]
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[[Category: Sundstrom M]]
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[[Category: Walker JR]]

Current revision

Human ubiquitin-conjugating enzyme E2 H

PDB ID 2z5d

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