2j7x

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[[Image:2j7x.gif|left|200px]]
 
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==STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5==
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The line below this paragraph, containing "STRUCTURE_2j7x", creates the "Structure Box" on the page.
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<StructureSection load='2j7x' size='340' side='right'caption='[[2j7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2j7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EST:ESTRADIOL'>EST</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2j7x| PDB=2j7x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7x OCA], [https://pdbe.org/2j7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7x RCSB], [https://www.ebi.ac.uk/pdbsum/2j7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESR2_RAT ESR2_RAT] Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER-alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j7x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j7x ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5'''
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==See Also==
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2J7X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7X OCA].
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[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bonn, T.]]
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[[Category: Bonn T]]
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[[Category: Brzozowski, A M.]]
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[[Category: Brzozowski AM]]
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[[Category: Carlquist, M.]]
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[[Category: Carlquist M]]
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[[Category: Engstrom, O.]]
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[[Category: Engstrom O]]
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[[Category: Gustaffson, J A.]]
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[[Category: Gustaffson J-A]]
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[[Category: Hubbard, R E.]]
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[[Category: Hubbard RE]]
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[[Category: Ljunggren, J.]]
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[[Category: Ljunggren J]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Thorsell, A G.]]
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[[Category: Thorsell A-G]]
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[[Category: Walton, J.]]
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[[Category: Walton J]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Coactivator]]
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[[Category: Corepressor]]
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[[Category: Dna-binding]]
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[[Category: Glycoprotein]]
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[[Category: Lipid-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear protein]]
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[[Category: Nuclear receptor]]
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[[Category: Phosphorylation]]
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[[Category: Receptor]]
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[[Category: Repressor]]
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[[Category: Steroid-binding]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:28:40 2008''
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Current revision

STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5

PDB ID 2j7x

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