3tgf

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(New page: 200px<br /> <applet load="3tgf" size="450" color="white" frame="true" align="right" spinBox="true" caption="3tgf" /> '''THE SOLUTION STRUCTURE OF HUMAN TRANSFORMIN...)
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[[Image:3tgf.gif|left|200px]]<br />
 
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<applet load="3tgf" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="3tgf" />
 
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'''THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA'''<br />
 
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==Overview==
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==THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA==
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The solution structure of transforming growth factor alpha has been, determined by a combination of high-resolution 1H-nuclear magnetic, resonance and distance geometry and restrained molecular dynamics. The 382, restraints derived from the NMR experiments were used to calculate many, distance geometry structures, which were then refined by restrained, molecular mechanics. Five of these structures were further refined using a, variety of methods. Comparison of independently measured parameters, such, as calculated hydrogen bonding patterns and experimental amide exchange, rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational, interconversion observed are suggested. Finally comparisons between this, work and others on this topic have been made.
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<StructureSection load='3tgf' size='340' side='right'caption='[[3tgf]], [[NMR_Ensembles_of_Models | 4 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tgf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2tgf|2tgf]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgf OCA], [http://pdbe.org/3tgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tgf RCSB], [http://www.ebi.ac.uk/pdbsum/3tgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN]] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/3tgf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3tgf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of transforming growth factor alpha has been determined by a combination of high-resolution 1H-nuclear magnetic resonance and distance geometry and restrained molecular dynamics. The 382 restraints derived from the NMR experiments were used to calculate many distance geometry structures, which were then refined by restrained molecular mechanics. Five of these structures were further refined using a variety of methods. Comparison of independently measured parameters, such as calculated hydrogen bonding patterns and experimental amide exchange rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational interconversion observed are suggested. Finally comparisons between this work and others on this topic have been made.
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==About this Structure==
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The solution structure of human transforming growth factor alpha.,Harvey TS, Wilkinson AJ, Tappin MJ, Cooke RM, Campbell ID Eur J Biochem. 1991 Jun 15;198(3):555-62. PMID:2050136<ref>PMID:2050136</ref>
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3TGF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3TGF OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The solution structure of human transforming growth factor alpha., Harvey TS, Wilkinson AJ, Tappin MJ, Cooke RM, Campbell ID, Eur J Biochem. 1991 Jun 15;198(3):555-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2050136 2050136]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 3tgf" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Campbell, I.D.]]
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<references/>
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[[Category: Cooke, R.M.]]
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__TOC__
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[[Category: Harvey, T.S.]]
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</StructureSection>
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[[Category: Tappin, M.J.]]
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[[Category: Human]]
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[[Category: Wilkinson, A.J.]]
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[[Category: Large Structures]]
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[[Category: growth factor]]
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[[Category: Campbell, I D]]
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[[Category: Cooke, R M]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:49:50 2007''
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[[Category: Harvey, T S]]
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[[Category: Tappin, M J]]
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[[Category: Wilkinson, A J]]
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[[Category: Growth factor]]

Current revision

THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA

PDB ID 3tgf

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