3ull

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(New page: 200px<br /> <applet load="3ull" size="450" color="white" frame="true" align="right" spinBox="true" caption="3ull, resolution 2.40&Aring;" /> '''HUMAN MITOCHONDRIAL...)
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[[Image:3ull.gif|left|200px]]<br />
 
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<applet load="3ull" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="3ull, resolution 2.40&Aring;" />
 
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'''HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN'''<br />
 
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==Overview==
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==HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN==
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We solved the crystal structure of the homotetrameric single-stranded DNA, binding (SSB) protein from human mitochondria at a resolution of 2.4 A., The tetramer is formed by two dimers interacting head-to-head and shows D2, symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes, and eukaryotic mitochondria; this is the first report of an atomic, resolution structure of this type of protein. Using biochemical data and, analysis of sequence homologies, we were able to correlate the functional, properties with structure. We propose that ssDNA wraps around the, tetrameric HsmtSSB protein through electropositive channels guided by, flexible loops.
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<StructureSection load='3ull' size='340' side='right'caption='[[3ull]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ull]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ULL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ull FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ull OCA], [https://pdbe.org/3ull PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ull RCSB], [https://www.ebi.ac.uk/pdbsum/3ull PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ull ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SSBP_HUMAN SSBP_HUMAN] This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/3ull_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ull ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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3ULL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3ULL OCA].
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*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution., Yang C, Curth U, Urbanke C, Kang C, Nat Struct Biol. 1997 Feb;4(2):153-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9033597 9033597]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Curth, U.]]
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[[Category: Curth U]]
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[[Category: Kang, C.]]
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[[Category: Kang C]]
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[[Category: Urbanke, C.]]
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[[Category: Urbanke C]]
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[[Category: Yang, C.]]
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[[Category: Yang C]]
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[[Category: dna replication]]
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[[Category: dna-binding protein]]
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[[Category: mitochondrion]]
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[[Category: transit peptide]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:49:55 2007''
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Current revision

HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN

PDB ID 3ull

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