2jso

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[[Image:2jso.gif|left|200px]]
 
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==Antimicrobial resistance protein==
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The line below this paragraph, containing "STRUCTURE_2jso", creates the "Structure Box" on the page.
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<StructureSection load='2jso' size='340' side='right'caption='[[2jso]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jso OCA], [https://pdbe.org/2jso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jso RCSB], [https://www.ebi.ac.uk/pdbsum/2jso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jso ProSAT]</span></td></tr>
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{{STRUCTURE_2jso| PDB=2jso | SCENE= }}
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</table>
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== Function ==
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'''Antimicrobial resistance protein'''
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[https://www.uniprot.org/uniprot/PMRD_ECOLI PMRD_ECOLI] Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosphorylation, and promotes the transcription of PmrA-activated genes responsible for polymyxin resistance. PmrD is the first protein identified to mediate the connectivity between two TCSs by protecting the phosphorylated response regulator of the downstream TCS. PmrD shows no homology to proteins with known structures. We present here the solution structure of PmrD from Escherichia coli, the first three-dimensional structure of the PmrD family. Our study provides the structural basis of the novel interacting mechanism of bacterial two-component signal-transduction systems.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jso_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2JSO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jso ConSurf].
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First structure of the polymyxin resistance proteins., Fu W, Yang F, Kang X, Zhang X, Li Y, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Oct 5;361(4):1033-7. Epub 2007 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17686460 17686460]
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<div style="clear:both"></div>
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[[Category: Escherichia coli]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Fu, W.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Jin, C.]]
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[[Category: Large Structures]]
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[[Category: Antibiotic resistance]]
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[[Category: Fu W]]
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[[Category: Protein]]
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[[Category: Jin C]]
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[[Category: Signaling protein]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:15:35 2008''
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Current revision

Antimicrobial resistance protein

PDB ID 2jso

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