2jyd

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[[Image:2jyd.jpg|left|200px]]
 
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==Structure of the fifth zinc finger of Myelin Transcription Factor 1==
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The line below this paragraph, containing "STRUCTURE_2jyd", creates the "Structure Box" on the page.
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<StructureSection load='2jyd' size='340' side='right'caption='[[2jyd]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jyd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JYD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2jyd| PDB=2jyd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyd OCA], [https://pdbe.org/2jyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jyd RCSB], [https://www.ebi.ac.uk/pdbsum/2jyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyd ProSAT]</span></td></tr>
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</table>
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'''Structure of the fifth zinc finger of Myelin Transcription Factor 1'''
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== Function ==
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[https://www.uniprot.org/uniprot/MYT1_MOUSE MYT1_MOUSE] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).<ref>PMID:9373037</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jyd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
Zinc binding domains, or zinc fingers (ZnFs), form one of the most numerous and most diverse superclasses of protein structural motifs in eukaryotes. Although our understanding of the functions of several classes of these domains is relatively well developed, we know much less about the molecular mechanisms of action of many others. Myelin transcription factor 1 (MyT1) type ZnFs are found in organisms as diverse as nematodes and mammals and are found in a range of sequence contexts. MyT1, one of the early transcription factors expressed in the developing central nervous system, contains seven MyT1 ZnFs that are very highly conserved both within the protein and between species. We have used a range of biophysical techniques, including NMR spectroscopy and data-driven macromolecular docking, to investigate the structural basis for the interaction between MyT1 ZnFs and DNA. Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
Zinc binding domains, or zinc fingers (ZnFs), form one of the most numerous and most diverse superclasses of protein structural motifs in eukaryotes. Although our understanding of the functions of several classes of these domains is relatively well developed, we know much less about the molecular mechanisms of action of many others. Myelin transcription factor 1 (MyT1) type ZnFs are found in organisms as diverse as nematodes and mammals and are found in a range of sequence contexts. MyT1, one of the early transcription factors expressed in the developing central nervous system, contains seven MyT1 ZnFs that are very highly conserved both within the protein and between species. We have used a range of biophysical techniques, including NMR spectroscopy and data-driven macromolecular docking, to investigate the structural basis for the interaction between MyT1 ZnFs and DNA. Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
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==About this Structure==
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Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.,Gamsjaeger R, Swanton MK, Kobus FJ, Lehtomaki E, Lowry JA, Kwan AH, Matthews JM, Mackay JP J Biol Chem. 2008 Feb 22;283(8):5158-67. Epub 2007 Dec 11. PMID:18073212<ref>PMID:18073212</ref>
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2JYD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYD OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1., Gamsjaeger R, Swanton MK, Kobus FJ, Lehtomaki E, Lowry JA, Kwan AH, Matthews JM, Mackay JP, J Biol Chem. 2008 Feb 22;283(8):5158-67. Epub 2007 Dec 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18073212 18073212]
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</div>
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<div class="pdbe-citations 2jyd" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Gamsjaeger R]]
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[[Category: Gamsjaeger, R.]]
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[[Category: Kobus FJ]]
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[[Category: Kobus, F J.]]
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[[Category: Kwan AH]]
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[[Category: Kwan, A H.]]
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[[Category: Lehtomaki E]]
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[[Category: Lehtomaki, E.]]
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[[Category: Lowry JA]]
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[[Category: Lowry, J A.]]
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[[Category: Mackay JP]]
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[[Category: Mackay, J P.]]
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[[Category: Matthews JM]]
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[[Category: Matthews, J M.]]
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[[Category: Swanton MK]]
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[[Category: Swanton, M K.]]
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[[Category: Alternative splicing]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Dna-binding]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Myt1]]
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[[Category: Neurogenesis]]
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[[Category: Nucleus]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:24:06 2008''
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Current revision

Structure of the fifth zinc finger of Myelin Transcription Factor 1

PDB ID 2jyd

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