2o1k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:56, 25 October 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2o1k.jpg|left|200px]]
 
-
<!--
+
==Structure of the extended diarrhea-inducing domain of rotavirus enterotoxigenic protein NSP4==
-
The line below this paragraph, containing "STRUCTURE_2o1k", creates the "Structure Box" on the page.
+
<StructureSection load='2o1k' size='340' side='right'caption='[[2o1k]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2o1k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_rotavirus_A/SA11 Simian rotavirus A/SA11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O1K FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
{{STRUCTURE_2o1k| PDB=2o1k | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o1k OCA], [https://pdbe.org/2o1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o1k RCSB], [https://www.ebi.ac.uk/pdbsum/2o1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o1k ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Structure of the extended diarrhea-inducing domain of rotavirus enterotoxigenic protein NSP4'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/NSP4_ROTS1 NSP4_ROTS1] Plays an essential role in the virus replication cycle by acting as a viroporin. Creates a pore in the host reticulum endoplasmic and as a consequence releases Ca(2+) in the cytoplasm of infected cell. In turn, high levels of cytoplasmic calcium trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication and immature particle assembly.[HAMAP-Rule:MF_04091]<ref>PMID:21151776</ref> <ref>PMID:7637021</ref> <ref>PMID:9108087</ref> The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.[HAMAP-Rule:MF_04091]<ref>PMID:17035333</ref> <ref>PMID:18587047</ref>
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
2O1K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_rotavirus_a/sa11 Simian rotavirus a/sa11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1K OCA].
+
Check<jmol>
-
[[Category: Simian rotavirus a/sa11]]
+
<jmolCheckbox>
-
[[Category: Single protein]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/2o1k_consurf.spt"</scriptWhenChecked>
-
[[Category: Deepa, R.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Rao, C Durga.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Suguna, K.]]
+
</jmolCheckbox>
-
[[Category: Nonstructural protein]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o1k ConSurf].
-
[[Category: Nsp4]]
+
<div style="clear:both"></div>
-
[[Category: Rotavirus enterotoxin]]
+
== References ==
-
[[Category: Tetrameric coiled-coil]]
+
<references/>
-
[[Category: Virulence]]
+
__TOC__
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:11:47 2008''
+
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Simian rotavirus A/SA11]]
 +
[[Category: Deepa R]]
 +
[[Category: Durga Rao C]]
 +
[[Category: Suguna K]]

Current revision

Structure of the extended diarrhea-inducing domain of rotavirus enterotoxigenic protein NSP4

PDB ID 2o1k

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o1k"
Personal tools