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1hkg

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(New page: 200px<br /> <applet load="1hkg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hkg, resolution 3.5&Aring;" /> '''STRUCTURAL DYNAMICS ...)
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[[Image:1hkg.gif|left|200px]]<br />
 
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<applet load="1hkg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hkg, resolution 3.5&Aring;" />
 
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'''STRUCTURAL DYNAMICS OF YEAST HEXOKINASE DURING CATALYSIS'''<br />
 
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==Overview==
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==STRUCTURAL DYNAMICS OF YEAST HEXOKINASE DURING CATALYSIS==
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The binding of the substrate glucose to yeast hexokinase results in a, substantial enzyme conformational change that is essential for catalysis, and may be important for the enzyme's specificity, as well as the control, of its activity. From high-resolution crystal structures of the monomeric, enzyme crystallized both in the presence and in the absence of glucose, we, find that glucose binds into the deep cleft that separates the molecule, into two lobes and causes these two lobes to move together and close off, the cleft. The structure of the hexokinase crystallized in the presence of, xylose and ADP is being determined at low resolution. In this crystal, form, the enzyme was thought to be in the conformation of the ternary, complex. However, a low-resolution structure of this crystal form shows, clearly that the enzyme is in the 'open' form and is not a ternary, complex. Crystals of the A isozyme with glucose and ADP may be. Further, chemically sequenced tryptic peptides are being incorporated into the, model obtained by crystallographic refinement at 2.1 A resolution., Completion of the sequence and the structure of the ternary complex should, allow a detailed description of the enzymatic mechanism of this kinase and, the role of substrate-induced conformational changes in catalysis and, control.
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<StructureSection load='1hkg' size='340' side='right'caption='[[1hkg]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hkg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The February 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''The Glycolytic Enzymes'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_2 10.2210/rcsb_pdb/mom_2004_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkg OCA], [https://pdbe.org/1hkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkg RCSB], [https://www.ebi.ac.uk/pdbsum/1hkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HXKA_YEAST HXKA_YEAST]
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==About this Structure==
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==See Also==
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1HKG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. The following page contains interesting information on the relation of 1HKG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb50_1.html The Glycolytic Enzymes]]. Active as [http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HKG OCA].
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*[[Hexokinase 3D structures|Hexokinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structural dynamics of yeast hexokinase during catalysis., Steitz TA, Shoham M, Bennett WS Jr, Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26;293(1063):43-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=6115422 6115422]
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[[Category: Large Structures]]
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[[Category: Hexokinase]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Protein complex]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: The Glycolytic Enzymes]]
[[Category: The Glycolytic Enzymes]]
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[[Category: Bennettjunior, W.S.]]
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[[Category: Bennett Jr WS]]
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[[Category: Steitz, T.A.]]
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[[Category: Steitz TA]]
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[[Category: transferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:01:21 2007''
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STRUCTURAL DYNAMICS OF YEAST HEXOKINASE DURING CATALYSIS

PDB ID 1hkg

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