2oiu

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[[Image:2oiu.gif|left|200px]]
 
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==L1 Ribozyme Ligase circular adduct==
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The line below this paragraph, containing "STRUCTURE_2oiu", creates the "Structure Box" on the page.
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<StructureSection load='2oiu' size='340' side='right'caption='[[2oiu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2oiu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2oiu| PDB=2oiu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oiu OCA], [https://pdbe.org/2oiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oiu RCSB], [https://www.ebi.ac.uk/pdbsum/2oiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oiu ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a ligase ribozyme that catalyzes regiospecific formation of a 5' to 3' phosphodiester bond between the 5'-triphosphate and the 3'-hydroxyl termini of two RNA fragments. Invariant residues form tertiary contacts that stabilize a flexible stem of the ribozyme at the ligation site, where an essential magnesium ion coordinates three phosphates. The structure of the active site permits us to suggest how transition-state stabilization and a general base may catalyze the ligation reaction required for prebiotic RNA assembly.
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'''L1 Ribozyme Ligase circular adduct'''
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The structural basis of ribozyme-catalyzed RNA assembly.,Robertson MP, Scott WG Science. 2007 Mar 16;315(5818):1549-53. PMID:17363667<ref>PMID:17363667</ref>
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==Overview==
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Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a ligase ribozyme that catalyzes regiospecific formation of a 5' to 3' phosphodiester bond between the 5'-triphosphate and the 3'-hydroxyl termini of two RNA fragments. Invariant residues form tertiary contacts that stabilize a flexible stem of the ribozyme at the ligation site, where an essential magnesium ion coordinates three phosphates. The structure of the active site permits us to suggest how transition-state stabilization and a general base may catalyze the ligation reaction required for prebiotic RNA assembly.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIU OCA].
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</div>
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<div class="pdbe-citations 2oiu" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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The structural basis of ribozyme-catalyzed RNA assembly., Robertson MP, Scott WG, Science. 2007 Mar 16;315(5818):1549-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17363667 17363667]
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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[[Category: Robertson, M P]]
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== References ==
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[[Category: Scott, W G.]]
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<references/>
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[[Category: Active site]]
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__TOC__
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[[Category: In vitro selection]]
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</StructureSection>
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[[Category: Ligase]]
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[[Category: Large Structures]]
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[[Category: Ribozyme]]
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[[Category: Robertson MP]]
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[[Category: Rna]]
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[[Category: Scott WG]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:00:21 2008''
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Current revision

L1 Ribozyme Ligase circular adduct

PDB ID 2oiu

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