2kin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="2kin" size="450" color="white" frame="true" align="right" spinBox="true" caption="2kin, resolution 2.&Aring;" /> '''KINESIN (MONOMERIC) F...)
Current revision (09:04, 21 February 2024) (edit) (undo)
 
(18 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2kin.gif|left|200px]]<br />
 
-
<applet load="2kin" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2kin, resolution 2.&Aring;" />
 
-
'''KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS'''<br />
 
-
==Overview==
+
==KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS==
-
We have determined the X-ray structure of rat kinesin head and neck, domains. The folding of the core motor domain resembles that of human, kinesin reported recently [Kull, F. J., et al. (1996) Nature 380, 550-554]. Novel features of the structure include the N-terminal region, folded as a beta-strand, and the C-terminal transition from the motor to, the rod domain, folded as two beta-strands plus an alpha-helix. This helix, is the beginning of kinesin's neck responsible for dimerization of the, motor complex and for force transduction. Although the folding of the, motor domain core is similar to that of a domain of myosin (an, actin-dependent motor), the position and angle of kinesin's neck are very, different from those of myosin's stalk, suggesting that the two motors, have different mechanisms of force transduction. The N- and C-terminal, ends of the core motor, thought to be responsible for the directionality, of the motors [Case, R. B., et al. (1997) Cell 90, 959-966], take the form, of beta-strands attached to the central beta-sheet of the structure.
+
<StructureSection load='2kin' size='340' side='right'caption='[[2kin]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2kin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The April 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Kinesin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_4 10.2210/rcsb_pdb/mom_2005_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kin OCA], [https://pdbe.org/2kin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kin RCSB], [https://www.ebi.ac.uk/pdbsum/2kin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kin ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KIF5C_RAT KIF5C_RAT] Microtubule-associated force-producing protein that may play a role in organelle transport (By similarity). Has ATPase activity (PubMed:27452403). Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431).[UniProtKB:O60282][UniProtKB:P28738]<ref>PMID:23576431</ref> <ref>PMID:27452403</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/2kin_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kin ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
2KIN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with SO4 and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2KIN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2KIN OCA].
+
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
X-ray structure of motor and neck domains from rat brain kinesin., Sack S, Muller J, Marx A, Thormahlen M, Mandelkow EM, Brady ST, Mandelkow E, Biochemistry. 1997 Dec 23;36(51):16155-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9405049 9405049]
+
__TOC__
 +
</StructureSection>
[[Category: Kinesin]]
[[Category: Kinesin]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
 +
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Biou, V.]]
+
[[Category: Biou V]]
-
[[Category: Brady, S.T.]]
+
[[Category: Brady ST]]
-
[[Category: Kozielski, F.]]
+
[[Category: Kozielski F]]
-
[[Category: Mandelkow, E.]]
+
[[Category: Mandelkow E]]
-
[[Category: Mandelkow, E.M.]]
+
[[Category: Mandelkow E-M]]
-
[[Category: Marx, A.]]
+
[[Category: Marx A]]
-
[[Category: Muller, J.]]
+
[[Category: Muller J]]
-
[[Category: Sack, S.]]
+
[[Category: Sack S]]
-
[[Category: Thormahlen, M.]]
+
[[Category: Thormahlen M]]
-
[[Category: ADP]]
+
-
[[Category: SO4]]
+
-
[[Category: cytoskeleton]]
+
-
[[Category: motor protein]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:08:59 2007''
+

Current revision

KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS

PDB ID 2kin

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kin"
Personal tools