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3kin
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="3kin" size="450" color="white" frame="true" align="right" spinBox="true" caption="3kin, resolution 3.1Å" /> '''KINESIN (DIMERIC) FR...) |
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| - | [[Image:3kin.gif|left|200px]]<br /> | ||
| - | <applet load="3kin" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="3kin, resolution 3.1Å" /> | ||
| - | '''KINESIN (DIMERIC) FROM RATTUS NORVEGICUS'''<br /> | ||
| - | == | + | ==KINESIN (DIMERIC) FROM RATTUS NORVEGICUS== |
| - | The dimeric form of the kinesin motor and neck domain from rat brain with | + | <StructureSection load='3kin' size='340' side='right'caption='[[3kin]], [[Resolution|resolution]] 3.10Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3kin]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. The April 2005 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Kinesin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2005_4 10.2210/rcsb_pdb/mom_2005_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3KIN FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3kin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kin OCA], [http://pdbe.org/3kin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kin RCSB], [http://www.ebi.ac.uk/pdbsum/3kin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kin ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/3kin_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kin ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography. The two heads of the dimer are connected via a coiled-coil alpha-helical interaction of their necks. They are broadly similar to one another; differences are most apparent in the head-neck junction and in a moderate reorientation of the neck helices in order to adopt to the coiled-coil conformation. The heads show a rotational symmetry (approximately 120 degrees) about an axis close to that of the coiled-coil. This arrangement is unexpected since it is not compatible with the microtubule lattice. In this arrangement, the two heads of a kinesin dimer could not have equivalent interactions with microtubules. | ||
| - | + | The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.,Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E Cell. 1997 Dec 26;91(7):985-94. PMID:9428521<ref>PMID:9428521</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3kin" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Kinesin 3D Structures|Kinesin 3D Structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Buffalo rat]] | ||
| + | [[Category: Kinesin]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
| + | [[Category: Biou, V]] | ||
| + | [[Category: Kozielski, F]] | ||
| + | [[Category: Mandelkow, E]] | ||
| + | [[Category: Mandelkow, E M]] | ||
| + | [[Category: Marx, A]] | ||
| + | [[Category: Sack, S]] | ||
| + | [[Category: Schonbrunn, E]] | ||
| + | [[Category: Thompson, A]] | ||
| + | [[Category: Thormahlen, M]] | ||
| + | [[Category: Cytoskeleton]] | ||
| + | [[Category: Motor protein]] | ||
Current revision
KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
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