2orh

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[[Image:2orh.gif|left|200px]]
 
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==Directing Macromolecular Conformation Through Halogen Bonds==
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The line below this paragraph, containing "STRUCTURE_2orh", creates the "Structure Box" on the page.
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<StructureSection load='2orh' size='340' side='right'caption='[[2orh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2orh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ORH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2orh| PDB=2orh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2orh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orh OCA], [https://pdbe.org/2orh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2orh RCSB], [https://www.ebi.ac.uk/pdbsum/2orh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2orh ProSAT]</span></td></tr>
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</table>
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'''Directing Macromolecular Conformation Through Halogen Bonds'''
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the assembly of small molecules in the design of supramolecular complexes and new materials. We demonstrate that a halogen bond formed between a brominated uracil and phosphate oxygen can be engineered to direct the conformation of a biological molecule, in this case to define the conformational isomer of a four-stranded DNA junction when placed in direct competition against a classic hydrogen bond. As a result, this bromine interaction is estimated to be approximately 2-5 kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to establish halogen bonding as a potential tool for the rational design and construction of molecular materials with DNA and other biological macromolecules.
The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the assembly of small molecules in the design of supramolecular complexes and new materials. We demonstrate that a halogen bond formed between a brominated uracil and phosphate oxygen can be engineered to direct the conformation of a biological molecule, in this case to define the conformational isomer of a four-stranded DNA junction when placed in direct competition against a classic hydrogen bond. As a result, this bromine interaction is estimated to be approximately 2-5 kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to establish halogen bonding as a potential tool for the rational design and construction of molecular materials with DNA and other biological macromolecules.
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==About this Structure==
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Directing macromolecular conformation through halogen bonds.,Voth AR, Hays FA, Ho PS Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:17379665<ref>PMID:17379665</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORH OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Directing macromolecular conformation through halogen bonds., Voth AR, Hays FA, Ho PS, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17379665 17379665]
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</div>
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[[Category: Hays, F A.]]
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<div class="pdbe-citations 2orh" style="background-color:#fffaf0;"></div>
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[[Category: Ho, P S.]]
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== References ==
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[[Category: Voth, A R.]]
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<references/>
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[[Category: Dna holliday junction]]
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__TOC__
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[[Category: Halogen bond]]
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</StructureSection>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:31:10 2008''
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[[Category: Large Structures]]
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[[Category: Hays FA]]
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[[Category: Ho PS]]
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[[Category: Voth AR]]

Current revision

Directing Macromolecular Conformation Through Halogen Bonds

PDB ID 2orh

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