2p1f

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[[Image:2p1f.jpg|left|200px]]
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==Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase)==
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<StructureSection load='2p1f' size='340' side='right' caption='[[2p1f]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2p1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P1F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eaw|2eaw]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1f OCA], [http://pdbe.org/2p1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p1f RCSB], [http://www.ebi.ac.uk/pdbsum/2p1f PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p1f ConSurf].
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<div style="clear:both"></div>
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<!--
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==See Also==
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The line below this paragraph, containing "STRUCTURE_2p1f", creates the "Structure Box" on the page.
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*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== References ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<references/>
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or leave the SCENE parameter empty for the default display.
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__TOC__
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-->
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</StructureSection>
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{{STRUCTURE_2p1f| PDB=2p1f | SCENE= }}
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[[Category: Human]]
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[[Category: Liu, Y]]
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'''Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase)'''
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[[Category: Pai, E F]]
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[[Category: Tang, H L]]
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==Disease==
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Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]
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==About this Structure==
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2P1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1F OCA].
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[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Liu, Y.]]
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[[Category: Pai, E F.]]
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[[Category: Tang, H L.]]
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[[Category: C-terminal domain]]
[[Category: C-terminal domain]]
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[[Category: Human]]
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[[Category: Hydrolase]]
[[Category: Orotidine 5'-monophosphate decarboxylase]]
[[Category: Orotidine 5'-monophosphate decarboxylase]]
[[Category: Ump synthase]]
[[Category: Ump synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:08:10 2008''
 

Current revision

Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase)

2p1f, resolution 1.76Å

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