2p5q

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[[Image:2p5q.jpg|left|200px]]
 
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==Crystal structure of the poplar glutathione peroxidase 5 in the reduced form==
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The line below this paragraph, containing "STRUCTURE_2p5q", creates the "Structure Box" on the page.
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<StructureSection load='2p5q' size='340' side='right'caption='[[2p5q]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_trichocarpa_x_Populus_deltoides Populus trichocarpa x Populus deltoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P5Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_2p5q| PDB=2p5q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5q OCA], [https://pdbe.org/2p5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p5q RCSB], [https://www.ebi.ac.uk/pdbsum/2p5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p5q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A3FNZ8_9ROSI A3FNZ8_9ROSI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p5q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p5q ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the poplar glutathione peroxidase 5 in the reduced form'''
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==See Also==
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*[[Glutathione peroxidase|Glutathione peroxidase]]
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__TOC__
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==Overview==
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</StructureSection>
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Glutathione peroxidases (GPXs) are a group of enzymes that regulate the levels of reactive oxygen species in cells and tissues, and protect them against oxidative damage. Contrary to most of their counterparts in animal cells, the higher plant GPX homologues identified so far possess cysteine instead of selenocysteine in their active site. Interestingly, the plant GPXs are not dependent on glutathione but rather on thioredoxin as their in vitro electron donor. We have determined the crystal structures of the reduced and oxidized form of Populus trichocarpaxdeltoides GPX5 (PtGPX5), using a selenomethionine derivative. PtGPX5 exhibits an overall structure similar to that of the known animal GPXs. PtGPX5 crystallized in the assumed physiological dimeric form, displaying a pseudo ten-stranded beta sheet core. Comparison of both redox structures indicates that a drastic conformational change is necessary to bring the two distant cysteine residues together to form an intramolecular disulfide bond. In addition, a computer model of a complex of PtGPX5 and its in vitro recycling partner thioredoxin h1 is proposed on the basis of the crystal packing of the oxidized form enzyme. A possible role of PtGPX5 as a heavy-metal sink is also discussed.
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[[Category: Large Structures]]
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[[Category: Populus trichocarpa x Populus deltoides]]
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==About this Structure==
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[[Category: Aubry A]]
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2P5Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Populus_trichocarpa_x_populus_deltoides Populus trichocarpa x populus deltoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5Q OCA].
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[[Category: Corbier C]]
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[[Category: Didierjean C]]
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==Reference==
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[[Category: Jacquot J-P]]
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Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes., Koh CS, Didierjean C, Navrot N, Panjikar S, Mulliert G, Rouhier N, Jacquot JP, Aubry A, Shawkataly O, Corbier C, J Mol Biol. 2007 Jul 13;370(3):512-29. Epub 2007 Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17531267 17531267]
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[[Category: Koh CS]]
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[[Category: Populus trichocarpa x populus deltoides]]
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[[Category: Mulliert G]]
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[[Category: Single protein]]
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[[Category: Navrot N]]
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[[Category: Aubry, A.]]
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[[Category: Panjikar S]]
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[[Category: Corbier, C.]]
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[[Category: Rouhier N]]
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[[Category: Didierjean, C.]]
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[[Category: Shawkataly O]]
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[[Category: Jacquot, J P.]]
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[[Category: Koh, C S.]]
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[[Category: Mulliert, G.]]
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[[Category: Navrot, N.]]
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[[Category: Panjikar, S.]]
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[[Category: Rouhier, N.]]
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[[Category: Shawkataly, O.]]
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[[Category: Thioredoxin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:25:21 2008''
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Current revision

Crystal structure of the poplar glutathione peroxidase 5 in the reduced form

PDB ID 2p5q

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