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1mco

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(New page: 200px<br /> <applet load="1mco" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mco, resolution 3.2&Aring;" /> '''THREE-DIMENSIONAL ST...)
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[[Image:1mco.gif|left|200px]]<br />
 
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<applet load="1mco" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1mco, resolution 3.2&Aring;" />
 
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'''THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION'''<br />
 
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==Overview==
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==THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION==
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X-ray analysis at 3.2-A resolution revealed that the Mcg IgG1 (lambda, chain) immunoglobulin is a compact T-shaped molecule. Because of the hinge, deletion, the Fc fragment lobe is pulled tightly upward into the junction, of the Fab arms. Along the molecular twofold axis, the Fab arms are joined, by an interchain disulfide bond between the two light chains. The antigen, combining sites consist of large irregular cavities at the tips of the Fab, regions. Potential complement (C1q) binding sites on Fc are sterically, shielded by the Fab arms, but putative attachment sites are accessible for, docking with the FcRI receptor on human monocytes and with protein A of, Staphylococcus aureus.
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<StructureSection load='1mco' size='340' side='right'caption='[[1mco]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mco]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MCO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GUP:ALPHA-L-GULOPYRANOSIDE'>GUP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mco OCA], [https://pdbe.org/1mco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mco RCSB], [https://www.ebi.ac.uk/pdbsum/1mco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mco ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mc/1mco_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mco ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1MCO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MCO OCA].
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Sandbox 20009|Sandbox 20009]]
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==Reference==
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*[[3D structures of human antibody|3D structures of human antibody]]
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Three-dimensional structure of a human immunoglobulin with a hinge deletion., Guddat LW, Herron JN, Edmundson AB, Proc Natl Acad Sci U S A. 1993 May 1;90(9):4271-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8483943 8483943]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Edmundson, A.B.]]
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[[Category: Edmundson AB]]
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[[Category: Guddat, L.W.]]
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[[Category: Guddat LW]]
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[[Category: immunoglobulin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:36:17 2007''
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Current revision

THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION

PDB ID 1mco

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