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1opg

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(New page: 200px<br /> <applet load="1opg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1opg, resolution 2.&Aring;" /> '''OPG2 FAB FRAGMENT'''<...)
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[[Image:1opg.gif|left|200px]]<br />
 
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<applet load="1opg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1opg, resolution 2.&Aring;" />
 
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'''OPG2 FAB FRAGMENT'''<br />
 
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==Overview==
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==OPG2 FAB FRAGMENT==
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Cell surface receptors called integrins mediate diverse cell adhesion, phenomena through recognition of the sequence arginine-glycine-aspartic, acid (RGD) present in proteins such as fibronectin and fibrinogen., Platelet aggregation in hemostasis is mediated by the binding of, fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the, gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an, arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the, heavy chain. The RYD loop and side chains are ordered in the 2.0-A, resolution crystal structure of the Fab fragment from this antireceptor, antibody. Moreover, the RYD loop assumes two clearly defined conformations, that may correspond to the orientations of the loop in the free state or, bound to integrin. This molecule will serve as a tool for understanding, protein-integrin recognition in platelet aggregation and other, RGD-mediated cell adhesion interactions.
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<StructureSection load='1opg' size='340' side='right'caption='[[1opg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [https://pdbe.org/1opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [https://www.ebi.ac.uk/pdbsum/1opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1opg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1opg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1opg ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1OPG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Sandbox 20009|Sandbox 20009]]
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==Reference==
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*[[3D structures of human antibody|3D structures of human antibody]]
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Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site., Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR, J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7836460 7836460]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ely, K.R.]]
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[[Category: Ely KR]]
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[[Category: Kodandapani, R.]]
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[[Category: Kodandapani R]]
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[[Category: Veerapandian, B.]]
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[[Category: Veerapandian B]]
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[[Category: cell adhesion molecule]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:39:22 2007''
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Current revision

OPG2 FAB FRAGMENT

PDB ID 1opg

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