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1oj9

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(New page: 200px<br /> <applet load="1oj9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oj9, resolution 2.3&Aring;" /> '''HUMAN MONOAMINE OXID...)
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[[Image:1oj9.gif|left|200px]]<br />
 
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<applet load="1oj9" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1oj9, resolution 2.3&Aring;" />
 
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'''HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH 1,4-DIPHENYL-2-BUTENE'''<br />
 
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==Overview==
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==HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH 1,4-DIPHENYL-2-BUTENE==
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Monoamine oxidase B (MAO-B) is an outer mitochondrial membrane-bound, enzyme that catalyzes the oxidative deamination of arylalkylamine, neurotransmitters and has been a target for a number of clinically used, drug inhibitors. The 1.7-A structure of the reversible isatin-MAO-B, complex has been determined; it forms a basis for the interpretation of, the enzyme's structure when bound to either reversible or irreversible, inhibitors. 1,4-Diphenyl-2-butene is found to be a reversible MAO-B, inhibitor, which occupies both the entrance and substrate cavity space in, the enzyme. Comparison of these two structures identifies Ile-199 as a, "gate" between the two cavities. Rotation of the side chain allows for, either separation or fusion of the two cavities. Inhibition of the enzyme, with ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12913124 (full description)]]
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<StructureSection load='1oj9' size='340' side='right'caption='[[1oj9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1oj9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OJ9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PB:1,4-DIPHENYL-2-BUTENE'>1PB</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oj9 OCA], [https://pdbe.org/1oj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oj9 RCSB], [https://www.ebi.ac.uk/pdbsum/1oj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oj9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/1oj9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oj9 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1OJ9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD and 1PB as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OJ9 OCA]].
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*[[Monoamine oxidase|Monoamine oxidase]]
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__TOC__
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==Reference==
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</StructureSection>
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Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures., Binda C, Li M, Hubalek F, Restelli N, Edmondson DE, Mattevi A, Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9750-5. Epub 2003 Aug 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12913124 12913124]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Binda, C.]]
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[[Category: Binda C]]
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[[Category: Edmondson, D.E.]]
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[[Category: Edmondson DE]]
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[[Category: Mattevi, A.]]
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[[Category: Mattevi A]]
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[[Category: 1PB]]
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[[Category: FAD]]
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[[Category: fad-containing amine oxidase]]
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[[Category: maob]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:14:52 2007''
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Current revision

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH 1,4-DIPHENYL-2-BUTENE

PDB ID 1oj9

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