2pva

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:22, 28 December 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2pva.gif|left|200px]]
 
-
<!--
+
==OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS==
-
The line below this paragraph, containing "STRUCTURE_2pva", creates the "Structure Box" on the page.
+
<StructureSection load='2pva' size='340' side='right'caption='[[2pva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2pva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PVA FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-
{{STRUCTURE_2pva| PDB=2pva | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pva OCA], [https://pdbe.org/2pva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pva RCSB], [https://www.ebi.ac.uk/pdbsum/2pva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pva ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/2pva_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pva ConSurf].
 +
<div style="clear:both"></div>
-
'''OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS'''
+
==See Also==
-
 
+
*[[Penicillin acylase|Penicillin acylase]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2PVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA].
+
[[Category: Large Structures]]
-
 
+
-
==Reference==
+
-
Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members., Suresh CG, Pundle AV, SivaRaman H, Rao KN, Brannigan JA, McVey CE, Verma CS, Dauter Z, Dodson EJ, Dodson GG, Nat Struct Biol. 1999 May;6(5):414-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10331865 10331865]
+
[[Category: Lysinibacillus sphaericus]]
[[Category: Lysinibacillus sphaericus]]
-
[[Category: Penicillin amidase]]
+
[[Category: Brannigan JA]]
-
[[Category: Single protein]]
+
[[Category: Dauter Z]]
-
[[Category: Brannigan, J A.]]
+
[[Category: Dodson EJ]]
-
[[Category: Dauter, Z.]]
+
[[Category: Dodson GG]]
-
[[Category: Dodson, E J.]]
+
[[Category: McVey CE]]
-
[[Category: Dodson, G G.]]
+
[[Category: Pundle AV]]
-
[[Category: McVey, C E.]]
+
[[Category: Rao KN]]
-
[[Category: Pundle, A V.]]
+
[[Category: SivaRaman H]]
-
[[Category: Rao, K N.]]
+
[[Category: Suresh CG]]
-
[[Category: SivaRaman, H.]]
+
[[Category: Verma CS]]
-
[[Category: Suresh, C G.]]
+
-
[[Category: Verma, C S.]]
+
-
[[Category: Amidohydrolase]]
+
-
[[Category: Ntn hydrolase]]
+
-
[[Category: Penicillin v acylase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:51:38 2008''
+

Current revision

OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS

PDB ID 2pva

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2pva"
Personal tools