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| - | [[Image:2qdz.jpg|left|200px]] | + | #REDIRECT [[4qky]] This PDB entry is obsolete and replaced by 4qky |
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| - | {{STRUCTURE_2qdz| PDB=2qdz | SCENE= }}
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| - | '''Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family'''
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| - | ==Overview==
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| - | In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB) superfamily are essential components of protein transport machineries. The TpsB transporter FhaC mediates the secretion of Bordetella pertussis filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of FhaC. The transporter comprises a 16-stranded beta barrel that is occluded by an N-terminal alpha helix and an extracellular loop and a periplasmic module composed of two aligned polypeptide-transport-associated (POTRA) domains. Functional data reveal that FHA binds to the POTRA 1 domain via its N-terminal domain and likely translocates the adhesin-repeated motifs in an extended hairpin conformation, with folding occurring at the cell surface. General features of the mechanism obtained here are likely to apply throughout the superfamily.
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| - | ==About this Structure==
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| - | 2QDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QDZ OCA].
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| - | ==Reference==
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| - | Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17702945 17702945]
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| - | [[Category: Bordetella pertussis]]
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| - | [[Category: Single protein]]
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| - | [[Category: Clantin, B.]]
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| - | [[Category: Jacob-Dubuisson, F.]]
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| - | [[Category: Villeret, V.]]
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| - | [[Category: Beta barrel]]
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| - | [[Category: Membrane]]
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| - | [[Category: Potra domain]]
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| - | [[Category: Protein transport]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:47:29 2008''
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