2r0b

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[[Image:2r0b.jpg|left|200px]]
 
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==Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein==
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The line below this paragraph, containing "STRUCTURE_2r0b", creates the "Structure Box" on the page.
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<StructureSection load='2r0b' size='340' side='right'caption='[[2r0b]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2r0b| PDB=2r0b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0b OCA], [https://pdbe.org/2r0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0b RCSB], [https://www.ebi.ac.uk/pdbsum/2r0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0b ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2r0b TOPSAN]</span></td></tr>
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</table>
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'''Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein'''
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== Function ==
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[https://www.uniprot.org/uniprot/STYX_HUMAN STYX_HUMAN] Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r0b_consurf.spt"</scriptWhenChecked>
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2R0B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0B OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r0b ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Bain, K T.]]
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[[Category: Bain KT]]
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[[Category: Bonanno, J B.]]
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[[Category: Bonanno JB]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Freeman, J.]]
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[[Category: Freeman J]]
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[[Category: Iizuka, M.]]
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[[Category: Iizuka M]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Romero R]]
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[[Category: Romero, R.]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M.]]
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[[Category: Smith D]]
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[[Category: Smith, D.]]
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[[Category: Wasserman S]]
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[[Category: Wasserman, S.]]
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[[Category: Hydrolase]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nysgxrc]]
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[[Category: Phosphatase]]
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[[Category: Protein phosphatase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:00:58 2008''
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Current revision

Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein

PDB ID 2r0b

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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