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2r20

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[[Image:2r20.gif|left|200px]]
 
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==Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.3 A (Br2)==
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The line below this paragraph, containing "STRUCTURE_2r20", creates the "Structure Box" on the page.
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<StructureSection load='2r20' size='340' side='right'caption='[[2r20]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r20]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R20 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2r20| PDB=2r20 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r20 OCA], [https://pdbe.org/2r20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r20 RCSB], [https://www.ebi.ac.uk/pdbsum/2r20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r20 ProSAT]</span></td></tr>
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</table>
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'''Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.3 A (Br2)'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Bombard S]]
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Metal ions play a key role in RNA folding and activity. Elucidating the rules that govern the binding of metal ions is therefore an essential step for better understanding the RNA functions. High-resolution data are a prerequisite for a detailed structural analysis of ion binding on RNA and, in particular, the observation of monovalent cations. Here, the high-resolution crystal structures of the tridecamer duplex r(GCGUUUGAAACGC) crystallized under different conditions provides new structural insights on ion binding on GAAA/UUU sequences that exhibit both unusual structural and functional properties in RNA. The present study extends the repertory of RNA ion binding sites in showing that the two first bases of UUU triplets constitute a specific site for sodium ions. A striking asymmetric pattern of metal ion binding in the two equivalent halves of the palindromic sequence demonstrates that sequence and its environment act together to bind metal ions. A highly ionophilic half that binds six metal ions allows, for the first time, the observation of a disodium cluster in RNA. The comparison of the equivalent halves of the duplex provides experimental evidences that ion binding correlates with structural alterations and groove contraction.
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[[Category: Timsit Y]]
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==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R20 OCA].
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==Reference==
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The 1.3 A resolution structure of the RNA tridecamer r(GCGUUUGAAACGC): metal ion binding correlates with base unstacking and groove contraction., Timsit Y, Bombard S, RNA. 2007 Dec;13(12):2098-107. Epub 2007 Oct 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17940138 17940138]
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[[Category: Bombard, S.]]
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[[Category: Timsit, Y.]]
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[[Category: Asymmetry]]
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[[Category: Electrostatic]]
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[[Category: Metal ion binding]]
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[[Category: Rna]]
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[[Category: Unstacking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:06:16 2008''
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Current revision

Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.3 A (Br2)

PDB ID 2r20

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