2r6a

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[[Image:2r6a.jpg|left|200px]]
 
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==Crystal Form BH1==
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The line below this paragraph, containing "STRUCTURE_2r6a", creates the "Structure Box" on the page.
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<StructureSection load='2r6a' size='340' side='right'caption='[[2r6a]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r6a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R6A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2r6a| PDB=2r6a | SCENE= }}
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2r6c|2r6c]], [[2r6d|2r6d]], [[2r6e|2r6e]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DnaB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980]), DnaG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6a OCA], [https://pdbe.org/2r6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r6a RCSB], [https://www.ebi.ac.uk/pdbsum/2r6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r6a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/DNAG_GEOSE DNAG_GEOSE]] RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.[HAMAP-Rule:MF_00974]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/2r6a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r6a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.
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'''Crystal Form BH1'''
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Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase.,Bailey S, Eliason WK, Steitz TA Science. 2007 Oct 19;318(5849):459-63. PMID:17947583<ref>PMID:17947583</ref>
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==Overview==
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The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2R6A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R6A OCA].
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</div>
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<div class="pdbe-citations 2r6a" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17947583 17947583]
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*[[Helicase 3D structures|Helicase 3D structures]]
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[[Category: Geobacillus stearothermophilus]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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[[Category: Protein complex]]
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== References ==
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[[Category: Bailey, S.]]
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<references/>
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[[Category: Eliason, W K.]]
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__TOC__
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[[Category: Steitz, T A.]]
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</StructureSection>
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[[Category: Atcc 12980]]
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[[Category: Large Structures]]
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[[Category: Bailey, S]]
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[[Category: Eliason, W K]]
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[[Category: Steitz, T A]]
[[Category: Dnab]]
[[Category: Dnab]]
[[Category: Dnag]]
[[Category: Dnag]]
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[[Category: Primase]]
[[Category: Primase]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:19:20 2008''
 

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Crystal Form BH1

PDB ID 2r6a

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