2rc3

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[[Image:2rc3.jpg|left|200px]]
 
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==Crystal structure of CBS domain, NE2398==
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The line below this paragraph, containing "STRUCTURE_2rc3", creates the "Structure Box" on the page.
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<StructureSection load='2rc3' size='340' side='right'caption='[[2rc3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rc3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nitrosomonas_europaea_ATCC_19718 Nitrosomonas europaea ATCC 19718]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RC3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_2rc3| PDB=2rc3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rc3 OCA], [https://pdbe.org/2rc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rc3 ProSAT], [https://www.topsan.org/Proteins/MCSG/2rc3 TOPSAN]</span></td></tr>
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</table>
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'''Crystal structure of CBS domain, NE2398'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q82SE2_NITEU Q82SE2_NITEU]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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We tested the general applicability of in situ proteolysis to form protein crystals suitable for structure determination by adding a protease (chymotrypsin or trypsin) digestion step to crystallization trials of 55 bacterial and 14 human proteins that had proven recalcitrant to our best efforts at crystallization or structure determination. This is a work in progress; so far we determined structures of 9 bacterial proteins and the human aminoimidazole ribonucleotide synthetase (AIRS) domain.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rc3_consurf.spt"</scriptWhenChecked>
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2RC3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Nitrosomonas_europaea_atcc_19718 Nitrosomonas europaea atcc 19718]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RC3 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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In situ proteolysis for protein crystallization and structure determination., Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Graslund S, Hammerstrom M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H, Nat Methods. 2007 Dec;4(12):1019-21. Epub 2007 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17982461 17982461]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rc3 ConSurf].
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[[Category: Nitrosomonas europaea atcc 19718]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Dong, A.]]
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</StructureSection>
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[[Category: Edwards, A M.]]
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[[Category: Large Structures]]
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[[Category: Joachimiak, A.]]
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[[Category: Nitrosomonas europaea ATCC 19718]]
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[[Category: Korniyenko, Y.]]
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[[Category: Dong A]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Edwards AM]]
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[[Category: Savchenko, A.]]
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[[Category: Joachimiak A]]
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[[Category: Walker, J R.]]
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[[Category: Korniyenko Y]]
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[[Category: Xu, X.]]
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[[Category: Savchenko A]]
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[[Category: Yakunin, A.]]
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[[Category: Walker JR]]
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[[Category: Zheng, H.]]
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[[Category: Xu X]]
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[[Category: Br]]
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[[Category: Yakunin A]]
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[[Category: Cbs domain]]
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[[Category: Zheng H]]
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[[Category: In situ proteolysis]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:37:46 2008''
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Current revision

Crystal structure of CBS domain, NE2398

PDB ID 2rc3

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