2trc

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[[Image:2trc.gif|left|200px]]
 
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==PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX==
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The line below this paragraph, containing "STRUCTURE_2trc", creates the "Structure Box" on the page.
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<StructureSection load='2trc' size='340' side='right'caption='[[2trc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2trc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TRC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2trc| PDB=2trc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2trc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2trc OCA], [https://pdbe.org/2trc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2trc RCSB], [https://www.ebi.ac.uk/pdbsum/2trc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2trc ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/2trc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2trc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of transducin's betagamma subunits complexed with phosducin, which regulates Gtbetagamma activity, has been solved to 2.4 angstroms resolution. Phosducin has two domains that wrap around Gtbetagamma to form an extensive interface. The N-terminal domain binds loops on the "top" Gtbeta surface, overlapping the Gtalpha binding surface, explaining how phosducin blocks Gtbetagamma's interaction with Gtalpha. The C-terminal domain shows structural homology to thioredoxin and binds the outer strands of Gtbeta's seventh and first blades in a manner likely to disrupt Gtbetagamma's normal orientation relative to the membrane and receptor. Phosducin's Ser-73, which when phosphorylated inhibits phosducin's function, points away from Gtbetagamma, toward a large flexible loop. Thus phosphorylation is not likely to affect the interface directly, but rather indirectly through an induced conformational change.
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'''PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX'''
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Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin.,Gaudet R, Bohm A, Sigler PB Cell. 1996 Nov 1;87(3):577-88. PMID:8898209<ref>PMID:8898209</ref>
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==Overview==
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The crystal structure of transducin's betagamma subunits complexed with phosducin, which regulates Gtbetagamma activity, has been solved to 2.4 angstroms resolution. Phosducin has two domains that wrap around Gtbetagamma to form an extensive interface. The N-terminal domain binds loops on the "top" Gtbeta surface, overlapping the Gtalpha binding surface, explaining how phosducin blocks Gtbetagamma's interaction with Gtalpha. The C-terminal domain shows structural homology to thioredoxin and binds the outer strands of Gtbeta's seventh and first blades in a manner likely to disrupt Gtbetagamma's normal orientation relative to the membrane and receptor. Phosducin's Ser-73, which when phosphorylated inhibits phosducin's function, points away from Gtbetagamma, toward a large flexible loop. Thus phosphorylation is not likely to affect the interface directly, but rather indirectly through an induced conformational change.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2TRC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TRC OCA].
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</div>
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<div class="pdbe-citations 2trc" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin., Gaudet R, Bohm A, Sigler PB, Cell. 1996 Nov 1;87(3):577-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8898209 8898209]
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*[[Transducin 3D structures|Transducin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bohm, A.]]
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[[Category: Bohm A]]
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[[Category: Gaudet, R.]]
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[[Category: Gaudet R]]
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[[Category: Sigler, P B.]]
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[[Category: Sigler PB]]
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[[Category: Beta-gamma]]
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[[Category: G protein]]
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[[Category: Meka]]
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[[Category: Phosducin]]
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[[Category: Phosphorylation]]
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[[Category: Regulation]]
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[[Category: Signal transduction]]
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[[Category: Thioredoxin]]
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[[Category: Transducin]]
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[[Category: Vision]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:26:08 2008''
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Current revision

PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX

PDB ID 2trc

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