1a1d

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(New page: 200px<br /><applet load="1a1d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a1d" /> '''YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINI...)
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[[Image:1a1d.gif|left|200px]]<br /><applet load="1a1d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1a1d" />
 
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'''YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINIMIZED AVERAGE STRUCTURE, ALPHA CARBONS ONLY'''<br />
 
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==Overview==
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==YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINIMIZED AVERAGE STRUCTURE, ALPHA CARBONS ONLY==
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RNA polymerase II subunit RPB8 is an essential subunit that is highly, conserved throughout eukaryotic evolution and is present in all three, types of nuclear RNA polymerases. We report the first high resolution, structural insight into eukaryotic RNA polymerase architecture with the, solution structure of RPB8 from Saccharomyces cerevisiae. It consists of, an eight stranded, antiparallel beta-barrel, four short helical regions, and a large, unstructured omega-loop. The strands are connected in classic, Greek-key fashion. The overall topology is unusual and contains a striking, C2 rotational symmetry. Furthermore, it is most likely a novel associate, of the oligonucleotide/oligosaccharide (OB) binding protein class.
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<StructureSection load='1a1d' size='340' side='right'caption='[[1a1d]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1a1d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A1D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1d OCA], [https://pdbe.org/1a1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a1d RCSB], [https://www.ebi.ac.uk/pdbsum/1a1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a1d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPAB3_YEAST RPAB3_YEAST] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/1a1d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a1d ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1A1D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A1D OCA].
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family., Krapp S, Kelly G, Reischl J, Weinzierl RO, Matthews S, Nat Struct Biol. 1998 Feb;5(2):110-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9461075 9461075]
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[[Category: Large Structures]]
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Kelly G]]
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[[Category: Kelly, G.]]
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[[Category: Krapp S]]
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[[Category: Krapp, S.]]
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[[Category: Matthews S]]
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[[Category: Matthews, S.]]
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[[Category: Reischl J]]
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[[Category: Reischl, J.]]
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[[Category: Weinzierl R]]
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[[Category: Weinzierl, R.]]
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[[Category: eukaryotic]]
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[[Category: nucleotidyltransferase]]
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[[Category: ob fold]]
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[[Category: rna polymerase]]
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[[Category: rpb8]]
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[[Category: yeast]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:32:51 2007''
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Current revision

YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINIMIZED AVERAGE STRUCTURE, ALPHA CARBONS ONLY

PDB ID 1a1d

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