2uux

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[[Image:2uux.jpg|left|200px]]
 
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==Structure of the tryptase inhibitor TdPI from a tick==
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The line below this paragraph, containing "STRUCTURE_2uux", creates the "Structure Box" on the page.
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<StructureSection load='2uux' size='340' side='right'caption='[[2uux]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2uux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UUX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2uux| PDB=2uux | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uux OCA], [https://pdbe.org/2uux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uux RCSB], [https://www.ebi.ac.uk/pdbsum/2uux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uux ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q1EG59_RHIAP Q1EG59_RHIAP]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TdPI, a tick salivary gland product related to Kunitz/BPTI proteins is a potent inhibitor of human beta-tryptase. Kinetic assays suggest that three of the four catalytic sites of tryptase are blocked by TdPI, and that the inhibition of one of these involves a peptide flanking the Kunitz head. In the course of the inhibition, tryptase cleaves TdPI at several positions. Crystal structures of the TdPI head, on its own and in complex with trypsin, reveal features that are not found in classical Kunitz/BPTI proteins and suggest the mode of interaction with tryptase. The loop of TdPI connecting the beta-sheet with the C-terminal alpha-helix is shortened, the disulphide-bridge pattern altered and N and C termini separated to produce a highly pointed molecule capable of penetrating the cramped active sites of tryptase. TdPI accumulates in the cytosolic granules of mast cells, presumably suppressing inflammation in the host animal's skin by tryptase inhibition.
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'''STRUCTURE OF THE TRYPTASE INHIBITOR TDPI FROM A TICK'''
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A tick protein with a modified Kunitz fold inhibits human tryptase.,Paesen GC, Siebold C, Harlos K, Peacey MF, Nuttall PA, Stuart DI J Mol Biol. 2007 May 11;368(4):1172-86. Epub 2007 Mar 14. PMID:17391695<ref>PMID:17391695</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2uux" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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2UUX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUX OCA].
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*[[Tryptase inhibitor|Tryptase inhibitor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rhipicephalus appendiculatus]]
[[Category: Rhipicephalus appendiculatus]]
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[[Category: Single protein]]
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[[Category: Harlos K]]
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[[Category: Harlos, K.]]
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[[Category: Nuttall PA]]
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[[Category: Nuttall, P A.]]
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[[Category: Paesen GC]]
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[[Category: Paesen, G C.]]
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[[Category: Peacey MF]]
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[[Category: Peacey, M F.]]
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[[Category: Siebold C]]
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[[Category: Siebold, C.]]
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[[Category: Stuart DI]]
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[[Category: Stuart, D I.]]
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[[Category: Tryptase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:32:11 2008''
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Current revision

Structure of the tryptase inhibitor TdPI from a tick

PDB ID 2uux

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