2v43

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[[Image:2v43.jpg|left|200px]]
 
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==Crystal structure of RseB: a sensor for periplasmic stress response in E. coli==
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The line below this paragraph, containing "STRUCTURE_2v43", creates the "Structure Box" on the page.
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<StructureSection load='2v43' size='340' side='right'caption='[[2v43]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v43]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V43 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene></td></tr>
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{{STRUCTURE_2v43| PDB=2v43 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v43 OCA], [https://pdbe.org/2v43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v43 RCSB], [https://www.ebi.ac.uk/pdbsum/2v43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v43 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RSEB_ECOLI RSEB_ECOLI] Seems to modulate the activity of RpoE (sigma-E).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v43_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v43 ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI'''
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==See Also==
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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__TOC__
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==Overview==
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</StructureSection>
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An elegant network of signal transduction has evolved in the bacterial cell envelope to respond to environmental stress. It is initiated by sensing unfavourable and harmful changes in the periplasm. The stress signal is then transmitted by a controlled degradation of the transmembrane anti-sigma-factor RseA that leads to the activation of the alternative sigma factor sigma(E). The periplasmic protein RseB exerts a crucial role in modulating the stability of RseA. RseB from Escherichia coli has been crystallized and crystal structures were determined at 2.4 A and at 2.8 A resolution. The protein forms a homodimer, with the monomer composed of two domains. The large domain resembles an unclosed beta-barrel that is structurally remarkably similar to a protein family capable of binding the lipid anchor of lipoproteins. The small C-terminal domain, connected to the large domain by a partially unstructured loop, is responsible for interaction with RseA. On the basis of the structure of RseB, we suggest that it acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response.
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[[Category: Large Structures]]
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[[Category: Wollmann P]]
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==About this Structure==
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[[Category: Zeth K]]
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2V43 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V43 OCA].
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==Reference==
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The structure of RseB: a sensor in periplasmic stress response of E. coli., Wollmann P, Zeth K, J Mol Biol. 2007 Sep 28;372(4):927-41. Epub 2007 Jun 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17692869 17692869]
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[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Wollmann, P.]]
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[[Category: Zeth, K.]]
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[[Category: Lipoprotein binding]]
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[[Category: Periplasmic]]
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[[Category: Regulator]]
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[[Category: Regulatory protein]]
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[[Category: Sensor for periplasmic stress]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:11:14 2008''
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Current revision

Crystal structure of RseB: a sensor for periplasmic stress response in E. coli

PDB ID 2v43

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