1abe

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(New page: 200px<br /><applet load="1abe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1abe, resolution 1.7&Aring;" /> '''NOVEL STEREOSPECIFICI...)
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[[Image:1abe.jpg|left|200px]]<br /><applet load="1abe" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1abe, resolution 1.7&Aring;" />
 
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'''NOVEL STEREOSPECIFICITY OF THE L-ARABINOSE-BINDING PROTEIN'''<br />
 
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==Overview==
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==NOVEL STEREOSPECIFICITY OF THE L-ARABINOSE-BINDING PROTEIN==
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Tertiary structure refinement at 1.7 A resolution of the liganded form of, L-arabinose-binding protein from Escherichia coli has revealed a novel, binding site geometry which accommodates both alpha- and beta-anomers of, L-arabinose. This detailed structure analysis provides new understanding, of protein-sugar interaction, the process by which the binding protein, minimizes the difference in the stability of the two bound sugar anomers, and the roles of periplasmic binding proteins in active transport.
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<StructureSection load='1abe' size='340' side='right'caption='[[1abe]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1abe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1abp 1abp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ABE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ABE FirstGlance]. <br>
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1ABE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure superseeds the now removed PDB entry 1ABP. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ABE OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARA:ALPHA-L-ARABINOSE'>ARA</scene>, <scene name='pdbligand=ARB:BETA-L-ARABINOSE'>ARB</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1abe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1abe OCA], [https://pdbe.org/1abe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1abe RCSB], [https://www.ebi.ac.uk/pdbsum/1abe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1abe ProSAT]</span></td></tr>
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Novel stereospecificity of the L-arabinose-binding protein., Quiocho FA, Vyas NK, Nature. 1984 Aug 2-8;310(5976):381-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=6379466 6379466]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARAF_ECOLI ARAF_ECOLI] Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D-galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/1abe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1abe ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Quiocho, F.A.]]
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[[Category: Quiocho FA]]
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[[Category: Vyas, N.K.]]
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[[Category: Vyas NK]]
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[[Category: binding protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:44:14 2007''
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NOVEL STEREOSPECIFICITY OF THE L-ARABINOSE-BINDING PROTEIN

PDB ID 1abe

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