This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2yzk
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2yzk.jpg|left|200px]] | ||
| - | < | + | ==Crystal structure of orotate phosphoribosyltransferase from Aeropyrum pernix== |
| - | + | <StructureSection load='2yzk' size='340' side='right'caption='[[2yzk]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2yzk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpx Aerpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YZK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yzk OCA], [http://pdbe.org/2yzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yzk RCSB], [http://www.ebi.ac.uk/pdbsum/2yzk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yzk ProSAT], [http://www.topsan.org/Proteins/RSGI/2yzk TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PYRE_AERPE PYRE_AERPE]] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yzk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yzk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | + | [[Category: Aerpx]] | |
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Orotate phosphoribosyltransferase]] | [[Category: Orotate phosphoribosyltransferase]] | ||
| - | + | [[Category: Baba, S]] | |
| - | [[Category: Baba, S | + | [[Category: Kanagawa, M]] |
| - | [[Category: Kanagawa, M | + | [[Category: Kawai, G]] |
| - | [[Category: Kawai, G | + | [[Category: Kuramitsu, S]] |
| - | [[Category: Kuramitsu, S | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Sampei, G]] |
| - | [[Category: Sampei, G | + | [[Category: Yokoyama, S]] |
| - | [[Category: Yokoyama, S | + | |
[[Category: Glycosyltransferase]] | [[Category: Glycosyltransferase]] | ||
[[Category: Magnesium]] | [[Category: Magnesium]] | ||
| Line 29: | Line 41: | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Pyrimidine biosynthesis]] | [[Category: Pyrimidine biosynthesis]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rossmann fold]] | [[Category: Rossmann fold]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:43:59 2008'' | ||
Current revision
Crystal structure of orotate phosphoribosyltransferase from Aeropyrum pernix
| |||||||||||
Categories: Aerpx | Large Structures | Orotate phosphoribosyltransferase | Baba, S | Kanagawa, M | Kawai, G | Kuramitsu, S | Structural genomic | Sampei, G | Yokoyama, S | Glycosyltransferase | Magnesium | National project on protein structural and functional analyse | Nppsfa | Pyrimidine biosynthesis | Rossmann fold | Rsgi | Transferase
