353d

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[[Image:353d.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF DOMAIN A OF THERMUS FLAVUS 5S RRNA AND THE CONTRIBUTION OF WATER MOLECULES TO ITS STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_353d", creates the "Structure Box" on the page.
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<StructureSection load='353d' size='340' side='right'caption='[[353d]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[353d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=353D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=353D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=353d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=353d OCA], [https://pdbe.org/353d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=353d RCSB], [https://www.ebi.ac.uk/pdbsum/353d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=353d ProSAT]</span></td></tr>
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{{STRUCTURE_353d| PDB=353d | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''CRYSTAL STRUCTURE OF DOMAIN A OF THERMUS FLAVUS 5S RRNA AND THE CONTRIBUTION OF WATER MOLECULES TO ITS STRUCTURE'''
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== Publication Abstract from PubMed ==
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==Overview==
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This is the first high resolution crystal structure of an RNA molecule made by solid phase chemical synthesis and representing a natural RNA. The structure of the domain A of Thermus flavus ribosomal 5S RNA is refined to R = 18% at 2.4 A including 159 solvent molecules. Most of the 2'-hydroxyl groups as well as the phosphate oxygens are involved either in specific hydrogen bonds in intermolecular contacts or to solvent molecules. The two U-G and G-U base-pairs are stabilized by H-bonds supplied via three water molecules to compensate for the lack of base-pair hydrogen bonds. The structure shows for the first time in detail the importance of highly ordered internal water in stabilizing an RNA structure.
This is the first high resolution crystal structure of an RNA molecule made by solid phase chemical synthesis and representing a natural RNA. The structure of the domain A of Thermus flavus ribosomal 5S RNA is refined to R = 18% at 2.4 A including 159 solvent molecules. Most of the 2'-hydroxyl groups as well as the phosphate oxygens are involved either in specific hydrogen bonds in intermolecular contacts or to solvent molecules. The two U-G and G-U base-pairs are stabilized by H-bonds supplied via three water molecules to compensate for the lack of base-pair hydrogen bonds. The structure shows for the first time in detail the importance of highly ordered internal water in stabilizing an RNA structure.
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==About this Structure==
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Crystal structure of domain A of Thermus flavus 5S rRNA and the contribution of water molecules to its structure.,Betzel C, Lorenz S, Furste JP, Bald R, Zhang M, Schneider TR, Wilson KS, Erdmann VA FEBS Lett. 1994 Sep 5;351(2):159-64. PMID:8082756<ref>PMID:8082756</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=353D OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of domain A of Thermus flavus 5S rRNA and the contribution of water molecules to its structure., Betzel C, Lorenz S, Furste JP, Bald R, Zhang M, Schneider TR, Wilson KS, Erdmann VA, FEBS Lett. 1994 Sep 5;351(2):159-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8082756 8082756]
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</div>
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[[Category: Bald, R.]]
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<div class="pdbe-citations 353d" style="background-color:#fffaf0;"></div>
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[[Category: Betzel, C.]]
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== References ==
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[[Category: Erdmann, V A.]]
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<references/>
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[[Category: Furste, J P.]]
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__TOC__
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[[Category: Lorenz, S.]]
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</StructureSection>
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[[Category: Schneider, T R.]]
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[[Category: Large Structures]]
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[[Category: Wilson, K S.]]
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[[Category: Bald R]]
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[[Category: Zhang, M.]]
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[[Category: Betzel C]]
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[[Category: A-rna]]
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[[Category: Erdmann VA]]
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[[Category: Double strand]]
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[[Category: Furste JP]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:16:53 2008''
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[[Category: Lorenz S]]
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[[Category: Schneider TR]]
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[[Category: Wilson KS]]
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[[Category: Zhang M]]

Current revision

CRYSTAL STRUCTURE OF DOMAIN A OF THERMUS FLAVUS 5S RRNA AND THE CONTRIBUTION OF WATER MOLECULES TO ITS STRUCTURE

PDB ID 353d

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