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377d

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[[Image:377d.gif|left|200px]]
 
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==5'-R(*CP*GP*UP*AP*CP*DG)-3'==
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The line below this paragraph, containing "STRUCTURE_377d", creates the "Structure Box" on the page.
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<StructureSection load='377d' size='340' side='right'caption='[[377d]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[377d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=377D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=377D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=377d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=377d OCA], [https://pdbe.org/377d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=377d RCSB], [https://www.ebi.ac.uk/pdbsum/377d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=377d ProSAT]</span></td></tr>
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{{STRUCTURE_377d| PDB=377d | SCENE= }}
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</table>
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__TOC__
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'''5'-R(*CP*GP*UP*AP*CP*G)-3''''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Biswas R]]
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==Overview==
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[[Category: Mitra SN]]
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The crystal structure of the alternating RNA r(CGUAC)dG with a 3'-terminal deoxy G residue has been determined at 1.76 A resolution. The crystal belongs to the orthorhombic space group C2221, unit-cell dimensions a = 29.53, b = 44.61 and c = 94.18 A, with two independent duplexes (I and II) per asymmetric unit. The structure was solved by the molecular-replacement method. The final R factor was 18.8% using 4757 reflections in the resolution range 8.0-1.76 A. The model contains a total of 496 atoms and 85 solvent molecules. The two duplexes form the repeating unit and stack in the usual head-to-tail (5',3'/5',3') fashion into a pseudocontinuous helical column. Almost all of the 2'-hydroxyl groups are engaged in the three modes of water-mediated interactions to the base N3/O2 atoms, the sugar O4' atoms and the backbone phosphates. Thus, the 2'-hydroxyl group of RNA is probably contributing to the stability of the duplexes.
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[[Category: Sundaralingam M]]
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==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=377D OCA].
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==Reference==
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1.76 A structure of a pyrimidine start alternating A-RNA hexamer r(CGUAC)dG., Biswas R, Mitra SN, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):570-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9761851 9761851]
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[[Category: Biswas, R.]]
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[[Category: Mitra, S N.]]
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[[Category: Sundaralingam, M.]]
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[[Category: A-rna]]
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:17:56 2008''
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Current revision

5'-R(*CP*GP*UP*AP*CP*DG)-3'

PDB ID 377d

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