379d

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[[Image:379d.gif|left|200px]]
 
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==THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE==
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The line below this paragraph, containing "STRUCTURE_379d", creates the "Structure Box" on the page.
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<StructureSection load='379d' size='340' side='right'caption='[[379d]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[379d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=379D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=379D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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{{STRUCTURE_379d| PDB=379d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=379d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=379d OCA], [https://pdbe.org/379d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=379d RCSB], [https://www.ebi.ac.uk/pdbsum/379d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=379d ProSAT]</span></td></tr>
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</table>
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'''THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE'''
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==See Also==
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*[[Ribozyme|Ribozyme]]
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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==Overview==
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__TOC__
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We have captured an 8.7 A conformational change that takes place in the cleavage site of the hammerhead ribozyme during self-cleavage, using X-ray crystallography combined with physical and chemical trapping techniques. This rearrangement brings the hammerhead ribozyme from the ground state into a conformation that is poised to form the transition state geometry required for hammerhead RNA self-cleavage. Use of a 5'-C-methylated ribose adjacent to the cleavage site permits this ordinarily transient conformational change to be kinetically trapped and observed crystallographically after initiating the hammerhead ribozyme reaction in the crystal. Cleavage of the corresponding unmodified hammerhead ribozyme in the crystal under otherwise identical conditions is faster than in solution, indicating that we have indeed trapped a catalytically relevant intermediate form of this RNA enzyme.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Beigelman L]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=379D OCA].
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[[Category: Karpeisky A]]
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[[Category: Maloney L]]
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==Reference==
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[[Category: Murray JB]]
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The structural basis of hammerhead ribozyme self-cleavage., Murray JB, Terwey DP, Maloney L, Karpeisky A, Usman N, Beigelman L, Scott WG, Cell. 1998 Mar 6;92(5):665-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9506521 9506521]
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[[Category: Scott WG]]
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[[Category: Beigelman, L.]]
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[[Category: Terwey DP]]
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[[Category: Karpeisky, A.]]
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[[Category: Usman N]]
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[[Category: Maloney, L.]]
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[[Category: Murray, J B.]]
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[[Category: Scott, W G.]]
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[[Category: Terwey, D P.]]
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[[Category: Usman, N.]]
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[[Category: Catalytic rna]]
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[[Category: Loop]]
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[[Category: Rna hammerhead ribozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:17:59 2008''
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THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE

PDB ID 379d

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