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399d

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[[Image:399d.gif|left|200px]]
 
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==STRUCTURE OF D(CGCCCGCGGGCG)==
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The line below this paragraph, containing "STRUCTURE_399d", creates the "Structure Box" on the page.
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<StructureSection load='399d' size='340' side='right'caption='[[399d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[399d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=399D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=399d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=399d OCA], [https://pdbe.org/399d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=399d RCSB], [https://www.ebi.ac.uk/pdbsum/399d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=399d ProSAT]</span></td></tr>
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{{STRUCTURE_399d| PDB=399d | SCENE= }}
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</table>
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__TOC__
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'''STRUCTURE OF D(CGCCCGCGGGCG)'''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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==Overview==
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[[Category: Fernandez LG]]
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We have determined the structure of the dodecamer duplex d(CGCCCGCGGGCG)2. A careful use of the molecular replacement programme AMoRe has been essential in order to solve the structure. This dodecamer shows a unique conformation, quite different from all the previously studied oligonucleotide duplexes: the central octamer has an A conformation, but with a sharp 65 degrees kink in the centre; the terminal base-steps have a B-like conformation; the major groove is completely closed in the centre, a hollow molecule is thus found. The results obtained confirm the high degree of variability of DNA structure. A new type of kink and an intermediate A/B double-helical conformation have been found. Such intermediate conformation differs from those described in DNA polymerase complexes.
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[[Category: Malinina L]]
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[[Category: Subirana JA]]
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==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA].
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==Reference==
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Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9917405 9917405]
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[[Category: Fernandez, L G.]]
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[[Category: Malinina, J A.Subirana L.]]
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:18:58 2008''
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Current revision

STRUCTURE OF D(CGCCCGCGGGCG)

PDB ID 399d

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