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1akm

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(New page: 200px<br /><applet load="1akm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1akm, resolution 2.8&Aring;" /> '''ORNITHINE TRANSCARBAM...)
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[[Image:1akm.gif|left|200px]]<br /><applet load="1akm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1akm, resolution 2.8&Aring;" />
 
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'''ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI'''<br />
 
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==About this Structure==
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==ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI==
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1AKM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Ornithine_carbamoyltransferase Ornithine carbamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.3 2.1.3.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AKM OCA].
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<StructureSection load='1akm' size='340' side='right'caption='[[1akm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1akm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akm OCA], [https://pdbe.org/1akm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akm RCSB], [https://www.ebi.ac.uk/pdbsum/1akm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OTC1_ECOLI OTC1_ECOLI] Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.<ref>PMID:3072022</ref> <ref>PMID:789338</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/1akm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1akm ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Crystal structure at 2.8 A resolution of anabolic ornithine transcarbamylase from Escherichia coli., Jin L, Seaton BA, Head JF, Nat Struct Biol. 1997 Aug;4(8):622-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9253409 9253409]
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*[[Ornithine carbamoyltransferase 3D structures|Ornithine carbamoyltransferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ornithine carbamoyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Head JF]]
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[[Category: Head, J.F.]]
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[[Category: Jin L]]
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[[Category: Jin, L.]]
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[[Category: Seaton B]]
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[[Category: Seaton, B.]]
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[[Category: anabolic]]
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[[Category: carbamyl phosphate]]
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[[Category: transferase]]
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[[Category: urea cycle]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:55:50 2007''
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Current revision

ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI

PDB ID 1akm

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