3b8m

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[[Image:3b8m.jpg|left|200px]]
 
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==Structure of FepE- Bacterial Polysaccharide Co-polymerase==
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The line below this paragraph, containing "STRUCTURE_3b8m", creates the "Structure Box" on the page.
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<StructureSection load='3b8m' size='340' side='right'caption='[[3b8m]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3b8m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B8M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8m OCA], [https://pdbe.org/3b8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b8m RCSB], [https://www.ebi.ac.uk/pdbsum/3b8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8m ProSAT]</span></td></tr>
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{{STRUCTURE_3b8m| PDB=3b8m | SCENE= }}
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</table>
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== Function ==
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'''Structure of FepE- Bacterial Polysaccharide Co-polymerase'''
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[https://www.uniprot.org/uniprot/Q8XBV8_ECO57 Q8XBV8_ECO57]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The chain length distribution of complex polysaccharides present on the bacterial surface is determined by polysaccharide co-polymerases (PCPs) anchored in the inner membrane. We report crystal structures of the periplasmic domains of three PCPs that impart substantially different chain length distributions to surface polysaccharides. Despite very low sequence similarities, they have a common protomer structure with a long central alpha-helix extending 100 A into the periplasm. The protomers self-assemble into bell-shaped oligomers of variable sizes, with a large internal cavity. Electron microscopy shows that one of the full-length PCPs has a similar organization as that observed in the crystal for its periplasmic domain alone. Functional studies suggest that the top of the PCP oligomers is an important region for determining polysaccharide modal length. These structures provide a detailed view of components of the bacterial polysaccharide assembly machinery.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b8m_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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3B8M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8M OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b8m ConSurf].
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Bacterial polysaccharide co-polymerases share a common framework for control of polymer length., Tocilj A, Munger C, Proteau A, Morona R, Purins L, Ajamian E, Wagner J, Papadopoulos M, Van Den Bosch L, Rubinstein JL, Fethiere J, Matte A, Cygler M, Nat Struct Mol Biol. 2008 Feb;15(2):130-8. Epub 2008 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18204465 18204465]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cygler, M.]]
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[[Category: Cygler M]]
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[[Category: Matte, A.]]
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[[Category: Matte A]]
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[[Category: Tocilj, A.]]
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[[Category: Tocilj A]]
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[[Category: Bacterial polysaccharide co-polymerase]]
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[[Category: Biosynthetic protein]]
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[[Category: Fepe]]
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[[Category: Metal transport]]
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[[Category: Wzz]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:31:17 2008''
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Current revision

Structure of FepE- Bacterial Polysaccharide Co-polymerase

PDB ID 3b8m

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