1i5z
From Proteopedia
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(New page: 200px<br /><applet load="1i5z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i5z, resolution 1.90Å" /> '''STRUCTURE OF CRP-CAM...) |
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| - | [[Image:1i5z.gif|left|200px]]<br /><applet load="1i5z" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1i5z, resolution 1.90Å" /> | ||
| - | '''STRUCTURE OF CRP-CAMP AT 1.9 A'''<br /> | ||
| - | == | + | ==STRUCTURE OF CRP-CAMP AT 1.9 A== |
| - | + | <StructureSection load='1i5z' size='340' side='right'caption='[[1i5z]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1i5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I5Z FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i5z OCA], [https://pdbe.org/1i5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i5z RCSB], [https://www.ebi.ac.uk/pdbsum/1i5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i5z ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/1i5z_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i5z ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fox RO]] | ||
| + | [[Category: Lee JC]] | ||
| + | [[Category: White MA]] | ||
Current revision
STRUCTURE OF CRP-CAMP AT 1.9 A
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