3bg0

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[[Image:3bg0.jpg|left|200px]]
 
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==Architecture of a Coat for the Nuclear Pore Membrane==
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The line below this paragraph, containing "STRUCTURE_3bg0", creates the "Structure Box" on the page.
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<StructureSection load='3bg0' size='340' side='right'caption='[[3bg0]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bg0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BG0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bg0 OCA], [https://pdbe.org/3bg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bg0 RCSB], [https://www.ebi.ac.uk/pdbsum/3bg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bg0 ProSAT]</span></td></tr>
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{{STRUCTURE_3bg0| PDB=3bg0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEC13_HUMAN SEC13_HUMAN] Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles.<ref>PMID:8972206</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bg0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bg0 ConSurf].
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<div style="clear:both"></div>
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'''Architecture of a Coat for the Nuclear Pore Membrane'''
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==See Also==
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Overview==
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<references/>
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The symmetric core of the nuclear pore complex can be considered schematically as a series of concentric cylinders. A peripheral cylinder coating the pore membrane contains the previously characterized, elongated heptamer that harbors Sec13-Nup145C in its middle section. Strikingly, Sec13-Nup145C crystallizes as a hetero-octamer in two space groups. Oligomerization of Sec13-Nup145C was confirmed biochemically. Importantly, the numerous interacting surfaces in the hetero-octamer are evolutionarily highly conserved, further underlining the physiological relevance of the oligomerization. The hetero-octamer forms a slightly curved, yet rigid rod of sufficient length to span the entire height of the proposed membrane-adjacent cylinder. In concordance with the dimensions and symmetry of the nuclear pore complex core, we suggest that the cylinder is constructed of four antiparallel rings, each ring being composed of eight heptamers arranged in a head-to-tail fashion. Our model proposes that the hetero-octamer would vertically traverse and connect the four stacked rings.
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__TOC__
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</StructureSection>
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==About this Structure==
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3BG0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BG0 OCA].
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==Reference==
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Architecture of a coat for the nuclear pore membrane., Hsia KC, Stavropoulos P, Blobel G, Hoelz A, Cell. 2007 Dec 28;131(7):1313-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18160040 18160040]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Hoelz, A.]]
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[[Category: Hoelz A]]
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[[Category: Autocatalytic cleavage]]
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[[Category: Hydrolase]]
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[[Category: Mrna transport]]
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[[Category: Npc]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Rna-binding]]
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[[Category: Translocation]]
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[[Category: Transport]]
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[[Category: Wd repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:43:51 2008''
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Current revision

Architecture of a Coat for the Nuclear Pore Membrane

PDB ID 3bg0

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