3bhh

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[[Image:3bhh.gif|left|200px]]
 
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==Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B)==
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The line below this paragraph, containing "STRUCTURE_3bhh", creates the "Structure Box" on the page.
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<StructureSection load='3bhh' size='340' side='right'caption='[[3bhh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bhh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BHH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CP:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]-6-(METHYLAMINO)PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>5CP</scene></td></tr>
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{{STRUCTURE_3bhh| PDB=3bhh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bhh OCA], [https://pdbe.org/3bhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bhh RCSB], [https://www.ebi.ac.uk/pdbsum/3bhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bhh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCC2B_HUMAN KCC2B_HUMAN] Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.<ref>PMID:16690701</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/3bhh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bhh ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B)'''
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==See Also==
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3BHH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHH OCA].
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__TOC__
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G.]]
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[[Category: Berridge G]]
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[[Category: Bullock, A.]]
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[[Category: Bullock A]]
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[[Category: Burgess, N.]]
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[[Category: Burgess N]]
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[[Category: Delft, F von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Niesen F]]
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[[Category: Niesen, F.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Pilka ES]]
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[[Category: Pilka, E S.]]
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[[Category: Rellos P]]
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[[Category: Rellos, P.]]
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[[Category: Ugochukwu E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Calcium/calmodulion dependent protein kinase ii beta]]
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[[Category: Calmodulin-binding]]
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[[Category: Cam kinase ii beta chain]]
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[[Category: Cam2]]
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[[Category: Camk ii beta subunit]]
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[[Category: Camk2]]
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[[Category: Camk2b]]
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[[Category: Ec:2 7.1 123]]
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[[Category: Mgc29528]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Proline rich calmodulin dependent protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:45:50 2008''
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Current revision

Crystal structure of human calcium/calmodulin-dependent protein kinase IIB isoform 1 (CAMK2B)

PDB ID 3bhh

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