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1aoj
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1aoj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aoj, resolution 2.5Å" /> '''THE SH3 DOMAIN OF EPS...) |
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| - | [[Image:1aoj.gif|left|200px]]<br /><applet load="1aoj" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1aoj, resolution 2.5Å" /> | ||
| - | '''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER'''<br /> | ||
| - | == | + | ==THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER== |
| - | SH3 domains are structurally well-characterized as monomeric modular units | + | <StructureSection load='1aoj' size='340' side='right'caption='[[1aoj]], [[Resolution|resolution]] 2.50Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1aoj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AOJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoj OCA], [https://pdbe.org/1aoj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aoj RCSB], [https://www.ebi.ac.uk/pdbsum/1aoj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aoj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EPS8_MOUSE EPS8_MOUSE] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.<ref>PMID:8404850</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ao/1aoj_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aoj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif. | ||
| - | + | The SH3 domain of Eps8 exists as a novel intertwined dimer.,Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002<ref>PMID:9303002</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1aoj" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Epidermal growth factor receptor substrate 3D structures|Epidermal growth factor receptor substrate 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Kishan KVR]] | ||
| + | [[Category: Newcomer ME]] | ||
Current revision
THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER
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