3bmz

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[[Image:3bmz.jpg|left|200px]]
 
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==Violacein biosynthetic enzyme VioE==
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The line below this paragraph, containing "STRUCTURE_3bmz", creates the "Structure Box" on the page.
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<StructureSection load='3bmz' size='340' side='right'caption='[[3bmz]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bmz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chromobacterium_violaceum_ATCC_12472 Chromobacterium violaceum ATCC 12472]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BMZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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{{STRUCTURE_3bmz| PDB=3bmz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bmz OCA], [https://pdbe.org/3bmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bmz RCSB], [https://www.ebi.ac.uk/pdbsum/3bmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bmz ProSAT]</span></td></tr>
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</table>
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'''Violacein biosynthetic enzyme VioE'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q7NSZ5_CHRVO Q7NSZ5_CHRVO]
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__TOC__
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==Overview==
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</StructureSection>
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VioE, an unusual enzyme with no characterized homologues, plays a key role in the biosynthesis of violacein, a purple pigment with antibacterial and cytotoxic properties. Without bound cofactors or metals, VioE, from the bacterium Chromobacterium violaceum, mediates a 1,2 shift of an indole ring and oxidative chemistry to generate prodeoxyviolacein, a precursor to violacein. Our 1.21 A resolution structure of VioE shows that the enzyme shares a core fold previously described for lipoprotein transporter proteins LolA and LolB. For both LolB and VioE, a bound polyethylene glycol molecule suggests the location of the binding and/or active site of the protein. Mutations of residues near the bound polyethylene glycol molecule in VioE have identified the active site and five residues important for binding or catalysis. This structural and mutagenesis study suggests that VioE acts as a catalytic chaperone, using a fold previously associated with lipoprotein transporters to catalyze the production of its prodeoxyviolacein product.
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[[Category: Chromobacterium violaceum ATCC 12472]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Drennan CL]]
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3BMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chromobacterium_violaceum Chromobacterium violaceum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BMZ OCA].
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[[Category: Ryan KS]]
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==Reference==
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The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins., Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL, J Biol Chem. 2008 Mar 7;283(10):6467-75. Epub 2008 Jan 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18171675 18171675]
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[[Category: Chromobacterium violaceum]]
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[[Category: Single protein]]
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[[Category: Drennan, C L.]]
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[[Category: Ryan, K S.]]
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[[Category: Biosynthetic protein]]
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[[Category: Violacein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:55:12 2008''
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Current revision

Violacein biosynthetic enzyme VioE

PDB ID 3bmz

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