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1aqy
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1aqy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aqy, resolution 1.75Å" /> '''ESTROGEN SULFOTRANSF...) |
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| - | [[Image:1aqy.gif|left|200px]]<br /><applet load="1aqy" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1aqy, resolution 1.75Å" /> | ||
| - | '''ESTROGEN SULFOTRANSFERASE WITH PAP'''<br /> | ||
| - | == | + | ==ESTROGEN SULFOTRANSFERASE WITH PAP== |
| - | The structure of estrogen sulphotransferase has been solved in the | + | <StructureSection load='1aqy' size='340' side='right'caption='[[1aqy]], [[Resolution|resolution]] 1.75Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1aqy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqy OCA], [https://pdbe.org/1aqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqy RCSB], [https://www.ebi.ac.uk/pdbsum/1aqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ST1E1_MOUSE ST1E1_MOUSE] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqy_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqy ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of estrogen sulphotransferase has been solved in the presence of inactive cofactor PAP and substrate 17 beta-estradiol. This structure reveals structural similarities between cytosolic sulphotransferases and nucleotide kinases. | ||
| - | + | Crystal structure of estrogen sulphotransferase.,Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC Nat Struct Biol. 1997 Nov;4(11):904-8. PMID:9360604<ref>PMID:9360604</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1aqy" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Carter CW]] | ||
| + | [[Category: Kakuta Y]] | ||
| + | [[Category: Negishi M]] | ||
| + | [[Category: Pedersen LC]] | ||
| + | [[Category: Pedersen LG]] | ||
Current revision
ESTROGEN SULFOTRANSFERASE WITH PAP
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