3c4h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:22, 30 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3c4h.jpg|left|200px]]
 
-
<!--
+
==Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313==
-
The line below this paragraph, containing "STRUCTURE_3c4h", creates the "Structure Box" on the page.
+
<StructureSection load='3c4h' size='340' side='right'caption='[[3c4h]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3c4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C4H FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DRL:2-METHYL-3,5,7,8-TETRAHYDRO-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE'>DRL</scene></td></tr>
-
{{STRUCTURE_3c4h| PDB=3c4h | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c4h OCA], [https://pdbe.org/3c4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c4h RCSB], [https://www.ebi.ac.uk/pdbsum/3c4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c4h ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/3c4h_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c4h ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Poly(ADP-ribose) polymerases (PARPs) activate DNA repair mechanisms upon stress- and cytotoxin-induced DNA damage, and inhibition of PARP activity is a lead in cancer drug therapy. We present a structural and functional analysis of the PARP domain of human PARP-3 in complex with several inhibitors. Of these, KU0058948 is the strongest inhibitor of PARP-3 activity. The presented crystal structures highlight key features for potent inhibitor binding and suggest routes for creating isoenzyme-specific PARP inhibitors.
-
'''Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313'''
+
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.,Lehtio L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarstrom M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schuler H, Karlberg T J Med Chem. 2009 May 14;52(9):3108-11. PMID:19354255<ref>PMID:19354255</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3c4h" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
3C4H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4H OCA].
+
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Berg, S Van den.]]
+
[[Category: Berglund H]]
-
[[Category: Berglund, H.]]
+
[[Category: Bountra C]]
-
[[Category: Bountra, C.]]
+
[[Category: Busam R]]
-
[[Category: Busam, R.]]
+
[[Category: Collins R]]
-
[[Category: Collins, R.]]
+
[[Category: Dahlgren LG]]
-
[[Category: Dahlgren, L G.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Flodin S]]
-
[[Category: Flodin, S.]]
+
[[Category: Flores A]]
-
[[Category: Flores, A.]]
+
[[Category: Graslund S]]
-
[[Category: Graslund, S.]]
+
[[Category: Hammarstrom M]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Herman MD]]
-
[[Category: Herman, M D.]]
+
[[Category: Johansson A]]
-
[[Category: Johansson, A.]]
+
[[Category: Johansson I]]
-
[[Category: Johansson, I.]]
+
[[Category: Kallas A]]
-
[[Category: Kallas, A.]]
+
[[Category: Karlberg T]]
-
[[Category: Karlberg, T.]]
+
[[Category: Kotenyova T]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Lehtio L]]
-
[[Category: Lehtio, L.]]
+
[[Category: Moche M]]
-
[[Category: Moche, M.]]
+
[[Category: Nilsson ME]]
-
[[Category: Nilsson, M E.]]
+
[[Category: Nordlund P]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nyman T]]
-
[[Category: Nyman, T.]]
+
[[Category: Persson C]]
-
[[Category: Persson, C.]]
+
[[Category: Sagemark J]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Svensson L]]
-
[[Category: Sagemark, J.]]
+
[[Category: Thorsell AG]]
-
[[Category: Svensson, L.]]
+
[[Category: Tresaugues L]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Van den Berg S]]
-
[[Category: Tresaugues, L.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Welin M]]
-
[[Category: Welin, M.]]
+
-
[[Category: Alternative splicing]]
+
-
[[Category: Catalytic fragment]]
+
-
[[Category: Enzyme-inhibitor complex]]
+
-
[[Category: Glycosyltransferase]]
+
-
[[Category: Nad]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transferase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:20:20 2008''
+

Current revision

Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313

PDB ID 3c4h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c4h"
Personal tools