3ckl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:29, 30 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ckl.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol==
-
The line below this paragraph, containing "STRUCTURE_3ckl", creates the "Structure Box" on the page.
+
<StructureSection load='3ckl' size='340' side='right'caption='[[3ckl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ckl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKL FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
-
{{STRUCTURE_3ckl| PDB=3ckl | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [https://pdbe.org/3ckl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB], [https://www.ebi.ac.uk/pdbsum/3ckl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckl ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ST1B1_HUMAN ST1B1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.<ref>PMID:9443824</ref> <ref>PMID:9463486</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckl_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckl ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol'''
+
==See Also==
-
 
+
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
3CKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Bochkarev A]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Dong, A.]]
+
[[Category: Dong A]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards AM]]
-
[[Category: Kozieradzki, I.]]
+
[[Category: Kozieradzki I]]
-
[[Category: Loppnau, P.]]
+
[[Category: Loppnau P]]
-
[[Category: Min, J.]]
+
[[Category: Min J]]
-
[[Category: Pan, P W.]]
+
[[Category: Pan PW]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Tempel W]]
-
[[Category: Tempel, W.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Human cytosolic sulfotransferase]]
+
-
[[Category: Lipid metabolism]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Resveratrol]]
+
-
[[Category: Sgc]]
+
-
[[Category: Steroid metabolism]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Sult1b1]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:52:17 2008''
+

Current revision

Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol

PDB ID 3ckl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ckl"
Personal tools