3mra

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[[Image:3mra.jpg|left|200px]]
 
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==M3 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 15 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_3mra", creates the "Structure Box" on the page.
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<StructureSection load='3mra' size='340' side='right'caption='[[3mra]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mra]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MRA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mra OCA], [https://pdbe.org/3mra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mra RCSB], [https://www.ebi.ac.uk/pdbsum/3mra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mra ProSAT]</span></td></tr>
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{{STRUCTURE_3mra| PDB=3mra | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACHA_TETCF ACHA_TETCF] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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'''M3 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 15 STRUCTURES'''
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==See Also==
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*[[Acetyl choline receptor 3D structures|Acetyl choline receptor 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The three-dimensional structure of a synthetic peptide corresponding to the putative transmembrane segment M3 (amino acid residues 277-301) of the alpha subunit of the nicotinic acetylcholine receptor from Torpedo californica has been studied by means of two-dimensional 1H-NMR spectroscopy in a chloroform/methanol (1:1) mixture containing 0.1 M LiClO4. Complete resonance assignment has been performed using double-quantum-filtered COSY (DQF-COSY), TOCSY and NOESY spectra. The spatial structure has been calculated using the Diana program on the basis of integrated intensities of NOESY spectra. HN-C(alpha)H and HC(alpha)-C(beta)H spin-spin coupling constants. Residues 279-297 of M3 form a right-handed helix (root mean square deviation is 0.032 nm for backbone atoms and 0.088 nm for all heavy atoms). The conformations of the 17 side chains have been unambiguously determined. The obtained structure is in accord with the photolabeling pattern of the membrane nicotinic acetylcholine receptor (nAChR) which suggests alpha-helical structure of M3 in the labeled portion [Blanton, M. P. &amp; Cohen, J. B. (1994) Biochemistry 33, 2859-2872].
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[[Category: Large Structures]]
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[[Category: Tetronarce californica]]
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==About this Structure==
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[[Category: Arseniev AS]]
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3MRA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRA OCA].
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[[Category: Cohen JB]]
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[[Category: Lugovskoy AA]]
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==Reference==
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[[Category: Maslennikov IV]]
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Spatial structure of the M3 transmembrane segment of the nicotinic acetylcholine receptor alpha subunit., Lugovskoy AA, Maslennikov IV, Utkin YN, Tsetlin VI, Cohen JB, Arseniev AS, Eur J Biochem. 1998 Jul 15;255(2):455-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9716388 9716388]
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[[Category: Tsetlin VI]]
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[[Category: Single protein]]
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[[Category: Utkin YN]]
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[[Category: Torpedo californica]]
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[[Category: Arseniev, A S.]]
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[[Category: Cohen, J B.]]
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[[Category: Lugovskoy, A A.]]
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[[Category: Maslennikov, I V.]]
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[[Category: Tsetlin, V I.]]
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[[Category: Utkin, Y N.]]
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[[Category: Alpha-helix]]
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[[Category: Ion-channel]]
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[[Category: Membrane protein]]
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[[Category: Receptor]]
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[[Category: Transmembrane segment]]
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[[Category: Transmembrane segment m3 of nachr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:07:21 2008''
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Current revision

M3 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 15 STRUCTURES

PDB ID 3mra

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