3php

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[[Image:3php.gif|left|200px]]
 
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==STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING==
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The line below this paragraph, containing "STRUCTURE_3php", creates the "Structure Box" on the page.
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<StructureSection load='3php' size='340' side='right'caption='[[3php]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3php]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3php FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3php OCA], [https://pdbe.org/3php PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3php RCSB], [https://www.ebi.ac.uk/pdbsum/3php PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3php ProSAT]</span></td></tr>
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{{STRUCTURE_3php| PDB=3php | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING'''
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== Publication Abstract from PubMed ==
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==Overview==
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The solution structure of an RNA-hairpin present in the pseudoknot, which is found at the 3'-terminus of turnip yellow mosaic virus genomic RNA, has been solved by nuclear magnetic resonance spectroscopy. The loop, which contains the sequence 5'-GGGUCA-3', was found to be highly structured and, contrary to expectations, does not attain its stability through GA or GC base pair formation but by triple interactions between the tilted adenosine and the minor groove sides of the first two guanosines. Interestingly, a very similar conformation was found for the cognate pseudoknot, implying that the 3'-hairpin is preformed for folding into a pseudoknotted structure. These findings suggest a mechanism of 'predetermined-fit' as a principle in RNA folding.
The solution structure of an RNA-hairpin present in the pseudoknot, which is found at the 3'-terminus of turnip yellow mosaic virus genomic RNA, has been solved by nuclear magnetic resonance spectroscopy. The loop, which contains the sequence 5'-GGGUCA-3', was found to be highly structured and, contrary to expectations, does not attain its stability through GA or GC base pair formation but by triple interactions between the tilted adenosine and the minor groove sides of the first two guanosines. Interestingly, a very similar conformation was found for the cognate pseudoknot, implying that the 3'-hairpin is preformed for folding into a pseudoknotted structure. These findings suggest a mechanism of 'predetermined-fit' as a principle in RNA folding.
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==About this Structure==
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Structure of the 3'-hairpin of the TYMV pseudoknot: preformation in RNA folding.,Kolk MH, van der Graaf M, Fransen CT, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW EMBO J. 1998 Dec 15;17(24):7498-504. PMID:9857204<ref>PMID:9857204</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of the 3'-hairpin of the TYMV pseudoknot: preformation in RNA folding., Kolk MH, van der Graaf M, Fransen CT, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW, EMBO J. 1998 Dec 15;17(24):7498-504. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9857204 9857204]
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</div>
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[[Category: Graaf, M Van Der.]]
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<div class="pdbe-citations 3php" style="background-color:#fffaf0;"></div>
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[[Category: Heus, H A.]]
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== References ==
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[[Category: Hilbers, C W.]]
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<references/>
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[[Category: Kolk, M H.]]
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__TOC__
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[[Category: Pleij, C W.A.]]
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</StructureSection>
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[[Category: Wijmenga, S S.]]
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[[Category: Large Structures]]
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[[Category: Pseudoknot]]
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[[Category: Heus HA]]
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[[Category: Ribonucleic acid]]
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[[Category: Hilbers CW]]
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[[Category: Rna]]
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[[Category: Kolk MH]]
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[[Category: Tymv]]
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[[Category: Pleij CWA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:10:30 2008''
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[[Category: Van Der Graaf M]]
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[[Category: Wijmenga SS]]

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STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING

PDB ID 3php

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