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| - | [[Image:414d.gif|left|200px]] | |
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| - | <!--
| + | ==5'-D(*GP*GP*GP*GP*CP*GP*CP*CP*CP*C)-3'== |
| - | The line below this paragraph, containing "STRUCTURE_414d", creates the "Structure Box" on the page.
| + | <StructureSection load='414d' size='340' side='right'caption='[[414d]], [[Resolution|resolution]] 1.90Å' scene=''> |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[414d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=414D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=414D FirstGlance]. <br> |
| - | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
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| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=414d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=414d OCA], [https://pdbe.org/414d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=414d RCSB], [https://www.ebi.ac.uk/pdbsum/414d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=414d ProSAT]</span></td></tr> |
| - | {{STRUCTURE_414d| PDB=414d | SCENE= }}
| + | </table> |
| - | | + | __TOC__ |
| - | '''5'-D(*GP*GP*GP*GP*CP*GP*CP*CP*CP*C)-3''''
| + | </StructureSection> |
| - | | + | [[Category: Large Structures]] |
| - | | + | [[Category: Savitha G]] |
| - | ==Overview== | + | [[Category: Viswamitra MA]] |
| - | The crystal and molecular structure of the self-complementary A-DNA decamer sequence d(G4CGC4) was solved at 1.9 A resolution. The decamer crystallizes in space group P21 with two independent duplexes in the asymmetric unit. Duplex 1 has interactions which are distributed symmetrically about its length compared with duplex 2. The two end base pairs of duplex 1 have a similar NH.O hydrogen-bond pattern involving GGC segments of duplex 2 and a symmetry-related neighbour, while the end base pairs of duplex 2 interact with the GCC and GGG segments of its symmetry-related neighbours through NH.O and NH.N hydrogen bonds and a water-mediated hydrogen bond between the carboxyl groups of C40 and C8. In addition to the C4'-C5' torsion angle gamma assuming the trans conformation in certain steps, this angle also adopts the gauche- conformation at C37 as opposed to the preferred gauche+ conformation, with a concomitant change in phosphodiester P-O5' (alpha) in the opposite sense. This facilitates stacking between adjacent bases. The study suggests that the structural alterations in the two molecules in the asymmetric unit originate from an inherent propensity of the d(G4CGC4) base sequence for varied intermolecular interactions and malleability.
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| - | ==About this Structure== | + | |
| - | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=414D OCA]. | + | |
| - | | + | |
| - | ==Reference== | + | |
| - | An A-DNA structure with two independent duplexes in the asymmetric unit., Savitha G, Viswamitra MA, Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1136-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10329775 10329775]
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| - | [[Category: Savitha, G.]] | + | |
| - | [[Category: Viswamitra, M. A.]] | + | |
| - | [[Category: A-dna]] | + | |
| - | [[Category: Double helix]] | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:16:38 2008''
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