417d

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[[Image:417d.gif|left|200px]]
 
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==A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE==
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The line below this paragraph, containing "STRUCTURE_417d", creates the "Structure Box" on the page.
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<StructureSection load='417d' size='340' side='right'caption='[[417d]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[417d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=417D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=417D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C46:6H,8H-3,4-DIHYDROPYRIMIDO[4,5-C][1,2]OXAZIN-7-0NE(CYTIDINE)-5-MONOPHOSPHATE'>C46</scene></td></tr>
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{{STRUCTURE_417d| PDB=417d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=417d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=417d OCA], [https://pdbe.org/417d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=417d RCSB], [https://www.ebi.ac.uk/pdbsum/417d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=417d ProSAT]</span></td></tr>
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</table>
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'''A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Brown DM]]
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The DNA hexamer d(CACGPG), in which dP is the ambivalent pyrimidine nucleoside analogue 2'-deoxy-beta-d-ribofuranosyl-(6H,8H-3, 4-dihydropyrimido[4,5-c][1,2]oxazin-7-one), crystallises as a left-handed Z-DNA duplex. X-ray analysis at 1.5 A shows that both P. A base-pairs are of the wobble type. This result appears inconsistent with other evidence from hybridisation and NMR studies of P-containing oligonucleotides, which suggests that, while P can form stable base-pairs with either A or G, thymine-like properties are more pronounced. Thermal denaturation experiments over a range of solution pH values indicate that protonation of the P.A base-pairs is unlikely to be responsible for the anomalous behaviour. No specific crystal packing effects can be identfied as an explanation, and it is concluded that base stacking and other interactions between nucleotide residues in Z-DNA are responsible.
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[[Category: Lin PKT]]
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[[Category: Loakes D]]
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==About this Structure==
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[[Category: Moore GS]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=417D OCA].
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[[Category: Moore MH]]
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[[Category: Schuerman MH]]
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==Reference==
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[[Category: Van Meervelt L]]
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A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex., Schuerman GS, Van Meervelt L, Loakes D, Brown DM, Kong Thoo Lin P, Moore MH, Salisbury SA, J Mol Biol. 1998 Oct 9;282(5):1005-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9753550 9753550]
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[[Category: Brown, D M.]]
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[[Category: Lin, P K.T.]]
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[[Category: Loakes, D.]]
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[[Category: Meervelt, L Van.]]
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[[Category: Moore, G S.]]
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[[Category: Moore, M H.]]
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[[Category: Schuerman, M H.]]
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[[Category: P a base-pair]]
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[[Category: Pyrimidine analogue]]
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[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:16:46 2008''
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Current revision

A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE

PDB ID 417d

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