5bna

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[[Image:5bna.jpg|left|200px]]
 
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==THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G==
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The line below this paragraph, containing "STRUCTURE_5bna", creates the "Structure Box" on the page.
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<StructureSection load='5bna' size='340' side='right'caption='[[5bna]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[5bna]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BNA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTN:PLATINUM+TRIAMINE+ION'>PTN</scene></td></tr>
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{{STRUCTURE_5bna| PDB=5bna | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bna OCA], [https://pdbe.org/5bna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bna RCSB], [https://www.ebi.ac.uk/pdbsum/5bna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bna ProSAT]</span></td></tr>
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</table>
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'''THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Dickerson RE]]
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When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge between Pt and the adjacent O6 atom of the same guanine. The entire guanine ring moves slightly toward the platinum site, into the major groove. Only three of the eight potential cisplatin binding sites on guanines actually are occupied, and this differential reactivity can be explained in terms of the relative freedom of motion of guanines toward the major groove. This shift of guanines upon ligation may weaken the glycosyl bond and assist in the depurination that leads to mismatch SOS repair and G.C. to T.A. transversion.
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[[Category: Drew HR]]
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[[Category: Pjura P]]
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==About this Structure==
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[[Category: Wing RM]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNA OCA].
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==Reference==
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The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G., Wing RM, Pjura P, Drew HR, Dickerson RE, EMBO J. 1984 May;3(5):1201-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6539674 6539674]
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[[Category: Dickerson, R E.]]
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[[Category: Drew, H R.]]
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[[Category: Pjura, P.]]
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[[Category: Wing, R M.]]
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[[Category: B-dna]]
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[[Category: Complexed with drug]]
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[[Category: Double helix]]
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[[Category: Modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:32:14 2008''
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Current revision

THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G

PDB ID 5bna

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