5er1

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[[Image:5er1.gif|left|200px]]
 
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==A rational approach to the design of antihypertensives. X-ray studies of complexes between aspartic proteinases and aminoalcohol renin inhibitors==
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The line below this paragraph, containing "STRUCTURE_5er1", creates the "Structure Box" on the page.
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<StructureSection load='5er1' size='340' side='right'caption='[[5er1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[5er1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ER1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ER1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HT:METHYL+N-[(2S,3S)-3-AMINO-2-HYDROXY-5-METHYLHEXYL]-L-VALYL-L-ISOLEUCYL-L-PHENYLALANINATE'>0HT</scene></td></tr>
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{{STRUCTURE_5er1| PDB=5er1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5er1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5er1 OCA], [https://pdbe.org/5er1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5er1 RCSB], [https://www.ebi.ac.uk/pdbsum/5er1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5er1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/5er1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5er1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Yeast enolase (2-phospho-D-glycerate hydrolyase, EC 4.2.1.11) has been crystallized by vapor diffusion and equilibrium dialysis of solutions of ammonium sulfate. The crystals with the dimer have 2-fold axial symmetry and appear to be suitable for high-resolution X-ray diffraction analysis. Our potential heavy-atom derivative of the native crystals has been prepared.
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'''A RATIONAL APPROACH TO THE DESIGN OF ANTIHYPERTENSIVES. X-RAY STUDIES OF COMPLEXES BETWEEN ASPARTIC PROTEINASES AND AMINOALCOHOL RENIN INHIBITORS'''
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Crystallization and preliminary crystallographic data for a tetragonal form of yeast enolase.,Lebioda L, Brewer JM J Mol Biol. 1984 Nov 25;180(1):213-5. PMID:006392568<ref>PMID:006392568</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5er1" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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5ER1 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ER1 OCA].
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*[[Pepsin|Pepsin]]
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[[Category: Hydrolase]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Blundell, T L.]]
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__TOC__
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[[Category: Cooper, J B.]]
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</StructureSection>
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[[Category: Foundling, S I.]]
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[[Category: Cryphonectria parasitica]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:33:56 2008''
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[[Category: Large Structures]]
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[[Category: Blundell TL]]
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[[Category: Cooper JB]]
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[[Category: Foundling SI]]

Current revision

A rational approach to the design of antihypertensives. X-ray studies of complexes between aspartic proteinases and aminoalcohol renin inhibitors

PDB ID 5er1

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